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Table 2 Adjusted hazard ratios and 95% confidence intervals of bladder cancer according to intake of vegetable stratified by subtype, sex and smoking status

From: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study

Study subgroup

Model adjustments

Vegetable intake (g/day)

HR per 1 SD increase (95% CI)

P-trend

Low (0–117)

Medium (117–221)

High (> 221)

Overall

No. Cases

962

916

1325

  

Model 1 d

Ref.

1.02 (0.91–1.13)

0.96 (0.86–1.07)

0.97 (0.91–1.02)

0.417

Model 2 d, e

Ref.

1.01 (0.90–1.11)

0.95 (0.85–1.07)

0.96 (0.91–1.01)

0.285

NMIBC

No. Cases

392

390

485

  

Model 1 d

Ref.

1.10 (0.94–1.28)

1.02 (0.85–1.22)

0.98 (0.90–1.06)

0.586

Model 2 d, e

Ref.

1.10 (0.94–1.28)

1.01 (0.84–1.21)

0.97 (0.89–1.05)

0.404

MIBC

No. Cases

167

213

393

  

Model 1 d

Ref.

1.12 (0.89–1.41)

1.00 (0.78–1.28)

0.98 (0.89–1.08)

0.682

Model 2 d, e

Ref.

1.12 (0.89–1.41)

0.99 (0.77–1.27)

0.97 (0.88–1.07)

0.582

Male

No. Cases

717

646

1042

  

Model 1 d

Ref.

1.03 (0.91–1.15)

1.02 (0.89–1.16)

1.00 (0.95–1.04)

0.826

Model 2 d, e

Ref.

1.02 (0.89–1.14)

1.01 (0.88–1.14)

0.99 (0.94–1.03)

0.905

Female

No. Cases

245

270

283

  

Model 1 d

Ref.

0.89 (0.74–1.06)

0.79 (0.64–0.98)

0.89 (0.81–0.99)

0.034

Model 2 d, e

Ref.

0.89 (0.74–1.07)

0.79 (0.64–0.98)

0.89 (0.81–0.99)

0.037

Never smoker

No. Cases

191

187

271

  

Model 1 d

Ref.

1.04 (0.85–1.28)

1.06 (0.84–1.35)

1.01 (0.91–1.10)

0.712

Model 2 d, e

Ref.

1.03 (0.83–1.26)

1.05 (0.82–1.34)

1.00 (0.90–1.09)

0.787

Current smoker

No. Cases

380

339

482

  

Model 1 d

Ref.

1.00 (0.87–1.14)

0.96 (0.80–1.15)

0.91 (0.83–1.01)

0.073

Model 2 d, e

Ref.

0.99 (0.85–1.16)

0.95 (0.79–1.14)

0.90 (0.84–1.00)

0.051

Former smoker

No. Cases

410

402

554

  

Model 1 d

Ref.

1.00 (0.86–1.16)

0.92 (0.78–1.10)

0.98 (0.95–1.07)

0.610

Model 2 d, e

Ref.

0.99 (0.85–1.15)

0.91 (0.77–1.09)

0.99 (0.94–1.09)

0.675

  1. dModel 1: Adjusted for age (years, continuous), sex (male or female, if applicable), smoking (if applicable, smoking was defined as 0 (never smokers); 1 [current light smokers (i.e. smoking less than 20 pack-years)]; 2 [current heavy smokers (i.e. smoking more than 20 pack-years)]; 3 [current smokers (no information on pack-years)]; 4 [former light smokers (i.e. smokers who ceased smoking over 1 year prior and smoked less than 20 pack-years)]; 5 [former heavy smokers (i.e. smokers who ceased smoking over 1 year prior and smoked more than 20 pack-years)]; 6 [former smokers (smokers who ceased smoking over 1 year prior and no information on pack-years)]) and total energy intake (kcal/day, continuous)
  2. d, eModel 2: Additionally, ethnicity (Caucasian or non-Caucasian, if applicable), alcohol intake (ml/day, continuous), fat intake (g/day, continuous), meat intake (g/day, continuous), sugar intake (g/day, continuous) and grain intake (g/day, continuous)
  3. Abbreviations: NMIBC, non-muscle invasive bladder cancer; MIBC, muscle invasive bladder cancer; SD, standard deviation; kcal, kilocalorie; g, gram
  4. Reference group was lowest intake (tertile 1)
  5. P-trend < 0.05 was considered statistically significant