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Table 3 Mortality rates and Kaplan-Meier estimates according to eGDR tertiles in subgroups, unadjusted and age-adjusted

From: Insulin resistance, diabetic kidney disease, and all-cause mortality in individuals with type 2 diabetes: a prospective cohort study

 

N

Events

Percent events

Events per 1000 patient-years

(95% CI) unadjusted

p

Events per 1000 patient-years

(95% CI)

age-adjusted

p

Age

 Below median value (n = 7829)

< 0.0001

 

< 0.0001

  T1

2803

238

8.5

10.52 (9.26–11.94)

Ref

16.29 (14.01–18.94)

Ref

  T2

2284

218

9.5

11.94 (10.45–13.63)

0.179 *

16.59 (14.33–19.21)

0.845*

  T3

2742

403

14.7

18.92 (17.16–20.86)

< 0.0001 *

< 0.0001 **

27.76 (24.57–31.36)

< 0.0001*

< 0.0001**

K-M log rank 63.68; p < 0.0001

Above median value (n = 7827)

 

0.042

 

< 0.0001

 T1

2415

837

34.7

50.20 (46.91–53.72)

Ref

19.08 (17.29–21.05)

Ref

 T2

2935

989

33,7

48.53 (45.60–51.65)

0.473 *

18.66 (17.01–20.48)

0.642*

 T3

2477

917

37.0

54.42 (51.01–58.06)

0.091 *

0.013 **

23.01 (21.04–25.16)

< 0.0001*

< 0.0001**

K-M log rank 7.02; p = 0.030

Gender

 Males (n = 8902)

< 0.0001

 

< 0.0001

  T1

3122

686

22.0

29.34 (27.23–31.62)

Ref

25.48 (23.53–27.60)

Ref

  T2

2988

736

24.6

33.50 (31.17–36.01)

0.013*

24.38 (22.51–26.40)

0.404*

  T3

2792

765

27.4

38.10 (35.49–40.90)

< 0.0001*

0.013**

34.15 (31.69–36.80)

< 0.0001*

< 0.0001**

K-M log rank 25.25; p < 0.0001

 Females (n = 6754)

  

0.002

 

< 0.0001

  T1

2096

389

18.6

24.42 (22.11–26.97)

Ref

16.21 (14.46–18.17)

Ref

  T2

2231

471

21.1

28.24 (25.80–30.91)

0.033*

16.54 (14.88–18.39)

0.764*

  T3

2427

555

22.9

30.72 (28.26–33.38)

0.180*

< 0.0001**

21.65 (19.71–23.79)

< 0.0001*

< 0.0001**

K-M log rank 12.55; p = 0.002

Prior CVD

 No (n = 12,036)

< 0.0001

 

< 0.0001

  T1

4329

728

16.8

21.80 (20.27–23.44)

Ref

18.38 (16.99–19.89)

Ref

  T2

3895

732

18.8

24.72 (22.99–26.57)

0.017*

17.60 (16.25–19.06)

0.403*

  T3

3812

773

20.3

26.89 (25.06–28.85)

< 0.0001*

0.103**

22.43 (20.80–24.18)

< 0.0001*

< 0.0001**

K-M Log rank 17.16; p < 0.0001

 Yes (n = 3620)

  

0.174

 

< 0.0001

  T1

889

347

39.0

58.74 (52.88–65.26)

Ref

37.96 (33.69–42.78)

Ref

  T2

1324

475

35.9

52.61 (48.08–57.56)

0.122*

33.81 (30.42–37.58)

0.105*

  T3

1407

547

38.9

58.19 (53.51–63.28)

0.890*

0.107**

46.58 (42.51–51.05)

0.003*

< 0.0001**

K-M log rank 3.60; p = 0.165

  1. eGDR estimated glucose disposal rate, CI confidence interval, CVD cardiovascular disease, K-M Kaplan-Meier. *p value vs T1; **p value vs T2
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