Insulin resistance, diabetic kidney disease, and all-cause mortality in individuals with type 2 diabetes: a prospective cohort study

Table 4 Mortality rates and Kaplan-Meier estimates according to eGDR tertiles by DKD phenotypes, unadjusted and age-adjusted

	N	Events	Percent events	Events per 1000 patient-years (95% CI) unadjusted	p	Events per 1000 patient-years (95% CI) age-adjusted	p
No DKD (n = 9984)					0.023		< 0.0001
T1	3837	553	14.4	18.44 (16.97–20.04)	Ref	17.24 (15.79–18.83)	Ref
T2	3294	504	14.3	19.78 (18.12–21.58)	0.257*	15.81 (14.41–17.36)	0.160*
T3	2853	479	16.8	21.93 (20.06–23.99)	0.006* 0.106**	20.47 (18.66–22.46)	0.007* < 0.0001**
K-M log rank 7.94; p = 0.019
Albuminuric DKD with preserved eGFR (n = 2966)					0.639		0.101
T1	719	199	27.7	38.48 (33.49–44.21)	Ref	30.89 (26.61–35.84)	Ref
T2	930	251	27.0	37.35 (33.00–42.27)	0.754*	29.42 (25.76–33.60)	0.610*
T3	1317	343	26.0	35.49 (31.93–39.46)	0.371* 0.542**	34.97 (31.37–38.99)	0.161* 0.037**
K-M log rank 0.93; p = 0.629
Nonalbuminuric DKD (n = 1476)					0.424		0.005
T1	389	155	39.8	59.36 (50.71–69,48)	Ref	27.48 (22.28–33.89)	Ref
T2	548	217	39.6	58.77 (51.44–67.13)	0.924*	26.59 (21.99–32.14)	0.754*
T3	539	232	43.0	65.94 (57.98–74.99)	0.307* 0.223**	35.78 (30.16–42.45)	0.010* 0.002**
K-M log rang 1.990; p = 0.370
Albuminuric DKD with reduced eGFR (n = 1230)					0.034		0.074
T1	273	168	61.5	109.36 (94.01–127.21)	Ref	67.64 (56.36–81.17)	Ref
T2	447	235	52.6	85.54 (75.27–97.20)	0.019*	53.62 (45.71–62.89)	0.026*
T3	510	266	52.2	85.00 (75.37–95.85)	0.014* 0.944**	60.21 (52.27–69.36)	0.251* 0.197**
K-M log rank 8.78; p = 0.012

DKD diabetic kidney disease, eGDR estimated glucose disposal rate, CI confidence interval, K-M Kaplan-Meier. *p value vs T1; **p value vs T2

ISSN: 1741-7015