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Fig. 4 | BMC Medicine

Fig. 4

From: Quantifying the potential value of antigen-detection rapid diagnostic tests for COVID-19: a modelling analysis

Fig. 4

Relative value of Ag-RDT vs NAT testing in a community setting. We assumed that in a community setting, the focus is on averting infection, and that any severe cases of respiratory disease are more likely to present in hospital settings (Fig. 3). Hence, in this setting, we focused on infectious person-days averted; we also assumed that individuals awaiting NAT results were not isolated during this time, owing to the infeasibility of doing so in this setting. a Scatter plot of the relative impact of Ag-RDT vs NAT (horizontal axis) vs the relative cost of Ag-RDT vs NAT (vertical axis). Dashed reference lines are as explained in Fig. 2 and in Additional file 3: Fig.S1. Of the yellow points (no NAT confirmation of Ag-RDT results), 98% fell in the favourable region shaded in grey; of the red points (confirm Ag-RDT negatives with a NAT), 80% fell in the favourable region. b Subgroup sensitivity analysis of the yellow points in a. Interpretation of PRCCs are as explained in Fig. 2 caption. Because the vast majority (98%) of simulations show Ag-RDT was favourable to NAT in this scenario, we did not conduct additional bivariate sensitivity analyses as for Figs. 2c and 3c

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