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Table 3 Associations of genetic proxies for antihypertensive drugs with albuminuria

From: Using Mendelian randomization study to assess the renal effects of antihypertensive drugs

Class

#SNPs

Odds ratio

95% CI

p

CCBs

8

0.58

0.37, 0.90

0.01

Alpha-adrenoceptor blockers

6

0.81

0.41, 1.60

0.54

Adrenergic neuron blockers

3

1.45

0.56, 3.75

0.44

Beta-adrenoceptor blockers

7

0.71

0.35, 1.46

0.35

Centrally acting antihypertensives

4

0.54

0.21, 1.39

0.20

Loop diuretics

2

1.39

0.43, 4.52

0.58

PSDs and aldosterone antagonists

3

1.17

0.41, 3.37

0.77

Thiazides and related diuretics

4

0.81

0.31, 2.11

0.66

Vasodilator antihypertensives

8

1.04

0.51, 2.14

0.92

  1. CCB, calcium channel blocker; PSD, potassium-sparing diuretic