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Table 4 Gender differences in prenatal dexamethasone exposure-induced the imbalance of fetal-placental-maternal bile acids circulation

From: Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

  Male Female
TBA level Up* Down*
Metabolomic spectrum of BAs
 TCA Up** N. S
 TMCA Up* N. S
Placental BA transporter
 Oatp2b1 Down** Down*
Placental nuclear receptor
 GR Up* N. S
  1. *P < 0.05, **P < 0.01 vs control. N. S no significant change, TBA total bile acid, BAs bile acids, TCA taurocholic acid, TCDCA tauro-chenodeoxycholic acid, TMCA tauro-muricholic acid, Oatp2b1 organic anion transporter polypeptide-related protein 2b1, GR glucocorticoid receptor