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Table 4 Gender differences in prenatal dexamethasone exposure-induced the imbalance of fetal-placental-maternal bile acids circulation

From: Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

 

Male

Female

TBA level

Up*

Down*

Metabolomic spectrum of BAs

 TCA

Up**

N. S

 TCDCA

Up*

N. S

 TMCA

Up*

N. S

Placental BA transporter

 Oatp2b1

Down**

Down*

Placental nuclear receptor

 GR

Up*

N. S

  1. *P < 0.05, **P < 0.01 vs control. N. S no significant change, TBA total bile acid, BAs bile acids, TCA taurocholic acid, TCDCA tauro-chenodeoxycholic acid, TMCA tauro-muricholic acid, Oatp2b1 organic anion transporter polypeptide-related protein 2b1, GR glucocorticoid receptor
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BMC Medicine

ISSN: 1741-7015

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