Table 3 Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with BF% and CAD (P_meta < 5 × 10^− 8; single trait P < 0.05)

rs2590942

1

72885281

T

G

4.98E−07

1.73E−03

6.166E−09

Intergenic

NEGR1

rs4970926

1

150673684

T

C

1.43E−03

3.99E−05

4.269E−08

Intron

ADAMTSL4,ANP32E,ANXA9,APH1A,ARNT,BNIPL,C1orf51,C1orf54,C1orf56,CA14,CDC42SE1,CTSK,CTSS,ECM1,ENSA,FAM63A,GOLPH3L,HORMAD1,KIAA0460,LASS2,LYSMD1,MCL1,MLLT11,MRPS21,PIP5K1A,PRPF3,PRUNE,RP11-68I18.1,SCNM1,SEMA6C,SETDB1,TARS2,TMOD4,TNFAIP8L2,VPS72

rs2133189

1

222814442

C

T

1.99E−02

2.42E−12

7.714E−09

Intron

AIDA,C1orf58,DISP1,FAM177B,HHIPL2,MIA3,TAF1A,TLR5

rs13396935

2

653195

G

A

1.42E−09

6.43E−04

2.493E−11

Regulatory Region

ACP1,FAM150B,LOC391343,SH3YL1,SNTG2,TMEM18

rs6435169

2

203753016

G

A

4.61E−02

7.54E−18

7.068E−10

Intron

ABI2,ALS2CR8,ALS2CR13,BMPR2,CYP20A1,ICA1L,NBEAL1,WDR12

rs10938397

4

45182527

A

G

1.36E−07

1.06E−03

1.176E−09

Intergenic

GNPDA2,GUF1

rs10455872

6

161010118

A

G

2.08E−02

5.73E−39

3.141E−28

Intron

IGF2R,LPA,LPAL2,MAP 3K4,PLG,SLC22A1,SLC22A2,SLC22A3

rs11226029

11

103693627

G

A

3.54E−02

1.14E−09

2.967E−11

Intron

DDI1,DYNC2H1,PDGFD

rs4842662

12

89933446

T

C

3.00E−05

7.13E−07

1.861E−11

Intron

ATP2B1,DUSP6,GALNT4,WDR51B

rs9532984

13

42634693

G

A,C,T

1.93E−02

1.62E−06

1.802E−08

Intron

AKAP11,DGKH,KIAA0564

rs3752958

14

100182687

C

A T

2.52E−02

7.98E−07

1.42E−08

Intron

BCL11B,CCNK,CYP46A1,DEGS2,EML1,EVL,HHIPL1,SETD3

rs1894400

15

91428955

C

T

1.95E−02

1.54E−07

1.118E−09

Intron

BLM,CRTC3,FES,FURIN,HDDC3,IQGAP1,MAN2A2,PRC1,RCCD1,SV2B,UNC45A,VPS33B

rs8050136

16

53816275

C

A

1.36E−25

4.65E−03

4.023E−19

Intron

AKTIP,CHD9,FTO,RBL2,RPGRIP1L

rs9906944

17

47091420

C

G,T

2.86E−08

1.17E−05

1.935E−12

Intron

ABI3,ATP5G1,B4GALNT2,C17orf92,CALCOCO2,GIP,GNGT2,HOXB1,HOXB2,HOXB3,HOXB4,HOXB5,HOXB6,HOXB7,HOXB8,HOXB9,HOXB13,IGF2BP1,NGFR,PHB,PHOSPHO1,SNF8,TTLL6,UBE2Z,ZNF652

rs4456565

17

58921974

T

C

4.22E−02

6.63E−07

3.104E−08

Intron

APPBP2,BCAS3,C17orf64,LOC729617,PPM1D,USP32

rs663129

18

57838401

G

A

1.47E−10

3.20E−08

3.097E−18

Intergenic

CCBE1,MC4R,PMAIP1