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Table 4 The bidirectional MR analysis of BF% levels and CVD traits

From: Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

Outcome

MR methods

Forward

Reserved

Causal effect size

SE

P value

Causal effect size

SE

P value

HF

IVW

0.488

0.138

4.16E−04

− 0.036

0.094

0.71

SMB

0.451

0.134

7.45E−04

− 0.067

0.142

0.64

WMB

0.456

0.132

5.46E−04

0.027

0.118

0.82

MR-RAPS

0.594

0.088

1.22E−11

− 0.036

0.099

0.72

MR-PRESSO

0.488

0.138

6.42E−03

−0.036

0.077

0.67

MR-Egger

1.452

0.571

0.03

0.323

0.290

0.35

CAD

IVW

0.264

0.330

0.42

0.014

0.051

0.78

SMB

0.437

0.175

0.01

− 0.010

0.043

0.81

WMB

0.491

0.165

2.93E−03

0.025

0.042

0.55

MR-RAPS

0.563

0.096

3.88E−09

0.008

0.028

0.78

MR-PRESSO

0.264

0.330

0.44

0.014

0.051

0.78

MR-Egger

− 0.152

1.617

0.93

− 0.013

0.115

0.91

  1. SE standard error, IVW inverse-variance weighted, SMB simple median, WMB weighted median, RAPS robust adjusted profile scores, PRESSO pleiotropy residual sum and outlier