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Table 4 The bidirectional MR analysis of BF% levels and CVD traits

From: Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

Outcome MR methods Forward Reserved
Causal effect size SE P value Causal effect size SE P value
HF IVW 0.488 0.138 4.16E−04 − 0.036 0.094 0.71
SMB 0.451 0.134 7.45E−04 − 0.067 0.142 0.64
WMB 0.456 0.132 5.46E−04 0.027 0.118 0.82
MR-RAPS 0.594 0.088 1.22E−11 − 0.036 0.099 0.72
MR-PRESSO 0.488 0.138 6.42E−03 −0.036 0.077 0.67
MR-Egger 1.452 0.571 0.03 0.323 0.290 0.35
CAD IVW 0.264 0.330 0.42 0.014 0.051 0.78
SMB 0.437 0.175 0.01 − 0.010 0.043 0.81
WMB 0.491 0.165 2.93E−03 0.025 0.042 0.55
MR-RAPS 0.563 0.096 3.88E−09 0.008 0.028 0.78
MR-PRESSO 0.264 0.330 0.44 0.014 0.051 0.78
MR-Egger − 0.152 1.617 0.93 − 0.013 0.115 0.91
  1. SE standard error, IVW inverse-variance weighted, SMB simple median, WMB weighted median, RAPS robust adjusted profile scores, PRESSO pleiotropy residual sum and outlier