Table 1 Information on outcome data sources
From: Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study
Data source | Cardiovascular disease | Population | Cases | Controls | Covariates adjusted in GWAS |
|---|---|---|---|---|---|
Consortium (Nielsen et al.) | Atrial fibrillation | European | 60,620 | 970,216 | Birth year, sex, genotype batch, and one to four principal components |
CARDIoGRAMplusC4D+UKBB | Coronary artery disease | Mixed | 122,733 | 424,528 | Not reported |
HERMES consortium | Heart failure | European | 47,309 | 930,014 | Age and sex, and principal components in individual studies where applicable |
MEGASTROKE consortium | Stroke | Â | 40,585 | 406,111 | Age and sex |
Ischemic stroke | Â | 34,217 | NA | ||
ISGC | Intracerebral hemorrhage | European | 3223 | 3725 | Age, sex, and principal components |
Consortium (Bakker et al.) | Subarachnoid hemorrhage | European | 7495 | 71,934 | Not reported |
The UK Biobank study (UKBB) | Aortic aneurysm | European | 2261 | 365,300 | Age, sex, and ten genetic principal components |
Aortic valve stenosis | 3528 | 364,033 | |||
Stroke | 12,036 | 355,525 | |||
Intracerebral hemorrhage | 1504 | 366,057 | |||
Ischemic stroke | 6566 | 360,995 | |||
Transient ischemic attack | 4813 | 362,748 | |||
Venous thromboembolism | 16,412 | 351,149 | |||
Peripheral vessel disease | 4593 | 362,968 | |||
The FinnGen consortium | Aortic aneurysm | European | 1919 | 167,843 | Age, sex, the first ten genetic principal components, and genotyping batch |
Atrial fibrillation | 17,325 | 97,214 | |||
Coronary artery disease | 16,631 | 160,268 | |||
Heart failure | 9576 | 159,286 | |||
Stroke | 14,171 | 133,027 | |||
Intracerebral hemorrhage | 1224 | 163,533 | |||
Subarachnoid hemorrhage | 1019 | 163,508 | |||
Ischemic stroke | 8046 | 164,286 | |||
Transient ischemic attack | 6729 | 164,286 | |||
Venous thromboembolism | 6913 | 169,986 | |||
Peripheral vessel disease | 5323 | 167,843 |