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Table 3 Hazard ratios (95% confidence intervals) of CVDs according to snus use in Swedish adults who reported never smoking cigarettes regularly, 2009ā€“2017

From: Swedish snuff (snus) and risk of cardiovascular disease and mortality: prospective cohort study of middle-aged and older individuals

Ā 

Snus use

Outcome and model (total number)

Nonusers

Users

Myocardial infarction (NĀ =ā€‰20,501)

ā€ƒTotal number of cases

852

21

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.35 (0.87ā€“2.10)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

1.36 (0.87ā€“2.11)

Heart failure (NĀ =ā€‰21,130)

ā€ƒTotal number of cases

1066

14

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.04 (0.61ā€“1.78)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

0.92 (0.54ā€“1.57)

Atrial fibrillation (NĀ =ā€‰19,852)

ā€ƒTotal number of cases

2193

43

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.33 (0.98ā€“1.81)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

1.29 (0.95ā€“1.75)

Total stroke* (NĀ =ā€‰20,620)

ā€ƒTotal number of cases

1160

24

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.57 (1.04ā€“2.37)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

1.53 (1.02ā€“2.32)

Total ischemic stroke (NĀ =ā€‰20,620)

ā€ƒTotal number of cases

957

21

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.69 (1.09ā€“2.63)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

1.65 (1.06ā€“2.57)

CVD mortality (NĀ =ā€‰18,189)

ā€ƒTotal number of deaths

780

15

ā€ƒAge and sex-adjusted model

1.00 (reference)

1.70 (1.01ā€“2.87)

ā€ƒMultivariable model 1ā€ 

1.00 (reference)

1.58 (0.94ā€“2.67)

  1. CI confidence interval, HR hazard ratio. Participants with a diagnosis of the corresponding CVD before the start of a follow-up, were excluded from the disease-specific analysis. In the analysis of overall CVD mortality, those who were diagnosed with CVD before the start of a follow-up were also excluded
  2. *Includes ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and undefined type of stroke
  3. ā€ The Cox proportional hazards regression model was adjusted for age (underlying time scale), sex (as a stratification variable), education, alcohol consumption, walking/bicycling, and exercise