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Table 4 CFP-10pep specificity in subgroups of the unlikely TB population

From: Evaluation of a serum-based antigen test for tuberculosis in HIV-exposed infants: a diagnostic accuracy study

Unlikely TB Total HIV-infected HIV-uninfected
CFP-10 (pos./total) Specificity % (95%CI) CFP-10 (pos./total) Specificity % (95%CI) CFP-10 (pos./total) Specificity % (95%CI)
NTM infection 2/14 85.7 (57.2–98.2) 1/12 91.7 (61.5–99.8) 1/2 50.0 (1.3–98.7)
Other infections* 13/153 91.5 (85.9–95.4) 11/88 87.5 (78.7–93.6) 2/65 96.9 (89.3–99.6)
Other inflammatory diseases 7/148 95.3 (90.5–98.1) 3/63 95.2 (86.7–99.0) 4/85 95.3 (88.4–98.7)
Other diseases 0/35 100 (90.0–100) 0/28 100 (87.7–100) 0/7 100 (59.0–100)
Latent TB infection 5/44 88.6 (75.4–96.2) 3/25 88.0 (68.8–97.5) 2/19 89.5 (66.9–98.7)
No disease (healthy) 1/45 97.8 (88.2–99.9) 1/27 96.3 (81.0–99.9) 0/18 100 (81.5–100)
Unclear diagnosis 0/5 100 (47.8–100) 0/1 100 (2.5–100) 0/4 100 (39.8–100)
Total 22/402# 94.5 (91.8–96.5) 15/218 93.1 (88.9–96.1) 7/184 96.2 (92.3–98.5)
  1. *Bacterial, viral, fungal, and other infections
  2. #Several children had co-infections, including 7 with non-tuberculous mycobacterium (NTM) infections and 12 with latent TB infections, while 23 children with latent TB infections also had an unrelated inflammatory disease