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Table 3 Vitamin D binding protein haplotypes and variants are associated with vitamin D status

From: Prevalence and predictors of vitamin D deficiency in young African children

Combination of genotypes

DBP Haplotypea

n/total (%)

25(OH)D levels (nmol/L)c

Unadjusted regression analyses of 25(OH)D levels

Adjusted regression analyses of 25(OH)D levels

Adjusted regression analyses 25(OH)D < 50 nmol/L

rs7041

rs4588

Medians (IQR)

Means (95% CI)

Beta (95% CI)

P

R2

Beta (95% CI)

P

OR (95% CI)

P

TT

CC

Gc1f/f

2689/3851 (69.8%)

77.7 (63.6, 93.0)

76.7 (75.8, 77.6)

Ref

–

0.009

Ref

–

Ref

–

TG

CC

Gc1f/s

514/3851 (13.4%)

79.2 (65.5, 96.0)

78.7 (76.6, 80.8)

0.03 (0.004, 0.05)

0.092

 

0.03 (− 0.0023, 0.05)

0.077

0.71 (0.47, 1.08)

0.11

TT

CA

Gc1f/2

525/3851 (13.6%)

72.7 (60.0, 86.8)

71.6 (69.7, 73.6)

− 0.07 (− 0.10, − 0.04)

< 0.0001

 

− 0.08 (− 0.11, − 0.05)

< 0.0001

1.79 (1.26, 2.55)

0.001

GG

CC

Gc1s/s

38/3851 (1.0%)

81.8 (61.0, 95.7)

77.8 (69.7, 86.9)

0.01 (− 0.08, 0.11)

0.78

 

0.01 (− 0.09, 0.10)

0.85

0.73 (0.16, 3.29)

0.69

TG

CA

Gc1s/2

66/3851 (1.7%)

74.6 (59.4, 87.6)

71.7 (66.1, 77.8)

− 0.07 (− 0.14, − 0.01)

0.081

 

− 0.08 (− 0.15, − 0.01)

0.026

1.18 (0.43, 3.30)

0.75

TT

AA

Gc2/2

19/3851 (0.5%)

63.9 (52.4, 79.7)

65.6 (58.0, 74.1)

− 0.16 (− 0.29, − 0.02)

0.027

 

− 0.18 (− 0.37, − 0.04)

0.009

2.34 (0.27, 20.40)

0.44

  

Gc variantb

          

T

C

Gc1f

6417/7702 (83.3%)

77.3 (63.5, 92.8)

76.5 (75.9, 77.0)

Ref

–

0.004

Ref

–

Ref

–

G

C

Gc1s

656/7702 (8.5%)

78.9 (63.8, 95.5)

77.9 (76.0, 79.7)

0.02 (− 0.01, 0.043)

0.15

 

0.02 (− 0.01, 0.04)

0.16

0.73 (0.52, 1.06)

0.096

T

A

Gc2

629/7702 (8.2%)

72.4 (59.4, 86.5)

71.3 (69.5, 73.1)

− 0.07 (− 0.10, − 0.04)

< 0.0001

 

− 0.08 (− 0.11, − 0.06)

< 0.0001

1.69 (1.23, 2.30)

0.001

  1. DBP vitamin D binding protein, Gc group-specific component, IQR inter-quartile range, n/a not available, 25(OH)D 25-hydroxyvitamin D, OR odds ratio, 95% CI 95% confidence interval
  2. a,bDBP haplotypes and Gc variants are based on combination of rs7041 and rs4588 genotypes. cMedian (IQR) and geometric means (95% CI) are presented. Percentage is based on the successfully typed DBP, some participants’ genotype data was not available or failed QC. DBP haplotype and Gc variant frequencies are presented by country in Additional file 7: Table S6
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BMC Medicine

ISSN: 1741-7015

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