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Table 3 Vitamin D binding protein haplotypes and variants are associated with vitamin D status

From: Prevalence and predictors of vitamin D deficiency in young African children

Combination of genotypes DBP Haplotypea n/total (%) 25(OH)D levels (nmol/L)c Unadjusted regression analyses of 25(OH)D levels Adjusted regression analyses of 25(OH)D levels Adjusted regression analyses 25(OH)D < 50 nmol/L
rs7041 rs4588 Medians (IQR) Means (95% CI) Beta (95% CI) P R2 Beta (95% CI) P OR (95% CI) P
TT CC Gc1f/f 2689/3851 (69.8%) 77.7 (63.6, 93.0) 76.7 (75.8, 77.6) Ref 0.009 Ref Ref
TG CC Gc1f/s 514/3851 (13.4%) 79.2 (65.5, 96.0) 78.7 (76.6, 80.8) 0.03 (0.004, 0.05) 0.092   0.03 (− 0.0023, 0.05) 0.077 0.71 (0.47, 1.08) 0.11
TT CA Gc1f/2 525/3851 (13.6%) 72.7 (60.0, 86.8) 71.6 (69.7, 73.6) − 0.07 (− 0.10, − 0.04) < 0.0001   − 0.08 (− 0.11, − 0.05) < 0.0001 1.79 (1.26, 2.55) 0.001
GG CC Gc1s/s 38/3851 (1.0%) 81.8 (61.0, 95.7) 77.8 (69.7, 86.9) 0.01 (− 0.08, 0.11) 0.78   0.01 (− 0.09, 0.10) 0.85 0.73 (0.16, 3.29) 0.69
TG CA Gc1s/2 66/3851 (1.7%) 74.6 (59.4, 87.6) 71.7 (66.1, 77.8) − 0.07 (− 0.14, − 0.01) 0.081   − 0.08 (− 0.15, − 0.01) 0.026 1.18 (0.43, 3.30) 0.75
TT AA Gc2/2 19/3851 (0.5%) 63.9 (52.4, 79.7) 65.6 (58.0, 74.1) − 0.16 (− 0.29, − 0.02) 0.027   − 0.18 (− 0.37, − 0.04) 0.009 2.34 (0.27, 20.40) 0.44
   Gc variantb           
T C Gc1f 6417/7702 (83.3%) 77.3 (63.5, 92.8) 76.5 (75.9, 77.0) Ref 0.004 Ref Ref
G C Gc1s 656/7702 (8.5%) 78.9 (63.8, 95.5) 77.9 (76.0, 79.7) 0.02 (− 0.01, 0.043) 0.15   0.02 (− 0.01, 0.04) 0.16 0.73 (0.52, 1.06) 0.096
T A Gc2 629/7702 (8.2%) 72.4 (59.4, 86.5) 71.3 (69.5, 73.1) − 0.07 (− 0.10, − 0.04) < 0.0001   − 0.08 (− 0.11, − 0.06) < 0.0001 1.69 (1.23, 2.30) 0.001
  1. DBP vitamin D binding protein, Gc group-specific component, IQR inter-quartile range, n/a not available, 25(OH)D 25-hydroxyvitamin D, OR odds ratio, 95% CI 95% confidence interval
  2. a,bDBP haplotypes and Gc variants are based on combination of rs7041 and rs4588 genotypes. cMedian (IQR) and geometric means (95% CI) are presented. Percentage is based on the successfully typed DBP, some participants’ genotype data was not available or failed QC. DBP haplotype and Gc variant frequencies are presented by country in Additional file 7: Table S6