Clinical indications of premenstrual disorders and subsequent risk of injury: a population-based cohort study in Sweden

Table 3 Associations of premenstrual disorders (PMD) with subsequent risk of injury, stratified by psychiatric comorbidities

	Population analysis				Sibling analysis ^a
	Reference N (IR)	PMD N (IR)	HR (95% CI) ^b	P for interaction	Reference N (IR)	PMD N (IR)	HR (95% CI) ^b	P for interaction
Any injury
By psychiatric comorbidities
No	306,980 (22.2)	1923 (23.1)	1.34 (1.28–1.40)	0.010	130,121 (21.5)	795 (23.2)	1.25 (1.08–1.41)	0.304
Yes	29,652 (46.6)	467 (46.7)	1.17 (1.06–1.28)	0.010	11,556 (44.1)	178 (45.3)	1.54 (1.01–2.07)	0.304
Suicidal behavior
By psychiatric comorbidities
No	12,678 (0.8)	70 (0.8)	1.76 (1.34–2.19)	0.437	5156 (0.7)	28 (0.7)	1.41 (0.48–2.34)	0.870
Yes	9742 (11.8)	146 (12.3)	1.60 (1.33–1.86)	0.437	3755 (11.1)	61 (13.3)	1.50 (0.29–2.70)	0.870
Accidents
By psychiatric comorbidities
No	288,068 (20.7)	1821 (21.7)	1.32 (1.26–1.38)	0.007	122,255 (20.1)	754 (22.0)	1.26 (1.09–1.43)	0.783
Yes	24,903 (34.8)	370 (34.5)	1.12 (1.00–1.24)	0.007	9750 (33.2)	141 (33.4)	1.37 (0.89–1.84)	0.783

N number, IR crude incidence rate per 1000 person-years, HR hazard ratio, CI confidence interval
^aAnalyses were stratified on full sister sets
^bHRs were controlled for attained age as the underlying timescale and additionally adjusted for calendar year of birth (1960–1965, 1966–1970, 1971–1975, 1976–1980, 1981–1985, or 1986–1990), educational level (primary school, high school, college and beyond, or unknown), region of residence (south, middle, or north of Sweden), and history of injury (yes or no)

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