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Table 3 Comparison of potential screening criteria at admission for definite meningitis (excluding children with possible meningitis only (Group C, n=51))

From: Clinical features of bacterial meningitis among hospitalised children in Kenya

Screening criteria

No. with criteria

No. with meningitis

Sensitivity % (95% CI)

Specificity % (95%CI)

PPV % (95% CI)

NPV % (95% CI)

NNLP (955% CI)

Bulging fontanela or neck stiffness

161

23

23.5 (15.5ā€“33.1)

98.9 (98.7ā€“99.1)

14.3 (9.3ā€“20.7)

99.4 (99.3ā€“99.5)

7 (5ā€“12)

Cyanosis or any of the above

207

23

23.5 (15.5ā€“33.1)

98.6 (98.3ā€“98.8)

11.1 (7.2ā€“16.2)

99.4 (99.3ā€“99.5)

10 (7ā€“16)

Seizures outside 6 months to 6 years or any of the above

771

33

33.7 (24.4ā€“43.9)

94.3 (93.8ā€“94.6)

4.3 (3.0ā€“6.0)

99.5 (99.3ā€“99.6)

27 (19ā€“43)

Focal seizures or any of the above

1023

39

39.8 (30.0ā€“50.2)

92.3 (91.9ā€“92.8)

3.8 (2.7ā€“5.2)

99.5 (99.4ā€“99.6)

30 (22ā€“47)

Impaired consciousness or any of the above

2659

57

58.2 (47.8ā€“68.1)

79.7 (79.0ā€“80.4)

2.1 (1.6ā€“2.8)

99.6 (99.5ā€“99.7)

57 (43ā€“85)

Fever without malaria parasitemia or any of the above

8099

84

85.7 (77.2ā€“92.0)

37.6 (36.7ā€“38.4)

1.0 (0.8ā€“1.3)

99.7 (99.5ā€“99.8)

134 (99ā€“208)

IMCI referral criteria: neck stiffness, lethargy, impaired consciousness, or seizures

4951

78

79.6 (70.3ā€“87.1)

62.0 (61.2ā€“62.9)

1.6 (1.3ā€“2.0)

99.7 (99.6ā€“99.8)

76 (59ā€“104)

  1. Abbreviations: CI confidence interval, PPV positive predictive values, NPV negative predictive value, NNLP number needed to lumbar puncture, IMCI integrated management of childhood infection
  2. ā€˜Or any of the aboveā€™ refers to the presence of ā‰„1 of the signs indicated in the preceding rows. This means that children represented on each row had the sign indicated on a particular row +/- any of the preceding signs. For example, 161 children had either bulging fontanel or neck stiffness (13 had both). 1023 children had ā‰„1 focal seizures, seizures outside the febrile convulsion age range, cyanosis, bulging fontanel, or neck stiffness (252 had focal seizures only while 771 had focal seizures and ā‰„1 of seizures outside the febrile convulsion age range, cyanosis, bulging fontanel, and neck stiffness [e.g. 76 had focal seizures which occurred outside the febrile convulsion age range; 1 had focal seizures which occurred outside the febrile convulsion age range and cyanosis])
  3. aBulging fontanel was only deemed present if the age was ā‰¤18 months