From: Clinical features of bacterial meningitis among hospitalised children in Kenya
Screening criteria | No. with criteria | No. with meningitis | Sensitivity % (95% CI) | Specificity % (95%CI) | PPV % (95% CI) | NPV % (95% CI) | NNLP (955% CI) |
---|---|---|---|---|---|---|---|
Bulging fontanela or neck stiffness | 161 | 23 | 23.5 (15.5ā33.1) | 98.9 (98.7ā99.1) | 14.3 (9.3ā20.7) | 99.4 (99.3ā99.5) | 7 (5ā12) |
Cyanosis or any of the above | 207 | 23 | 23.5 (15.5ā33.1) | 98.6 (98.3ā98.8) | 11.1 (7.2ā16.2) | 99.4 (99.3ā99.5) | 10 (7ā16) |
Seizures outside 6 months to 6 years or any of the above | 771 | 33 | 33.7 (24.4ā43.9) | 94.3 (93.8ā94.6) | 4.3 (3.0ā6.0) | 99.5 (99.3ā99.6) | 27 (19ā43) |
Focal seizures or any of the above | 1023 | 39 | 39.8 (30.0ā50.2) | 92.3 (91.9ā92.8) | 3.8 (2.7ā5.2) | 99.5 (99.4ā99.6) | 30 (22ā47) |
Impaired consciousness or any of the above | 2659 | 57 | 58.2 (47.8ā68.1) | 79.7 (79.0ā80.4) | 2.1 (1.6ā2.8) | 99.6 (99.5ā99.7) | 57 (43ā85) |
Fever without malaria parasitemia or any of the above | 8099 | 84 | 85.7 (77.2ā92.0) | 37.6 (36.7ā38.4) | 1.0 (0.8ā1.3) | 99.7 (99.5ā99.8) | 134 (99ā208) |
IMCI referral criteria: neck stiffness, lethargy, impaired consciousness, or seizures | 4951 | 78 | 79.6 (70.3ā87.1) | 62.0 (61.2ā62.9) | 1.6 (1.3ā2.0) | 99.7 (99.6ā99.8) | 76 (59ā104) |