Fig. 1

Positive findings, by impact, in a cohort of 10,478 individuals. The asterisk indicates that a genotype was considered high impact when the variants were P/LP and conveyed a substantial risk for disease with substantial burden that requires serious clinical diagnostic and management interventions to prevent or reduce risk from cancer or cardiovascular disease. The dagger indicates that a genotype was considered moderate impact when it contained pathogenic (low penetrance) variants or increased risk alleles (described in the “Methods” section) associated with diseases for which individuals could derive benefit from enhanced surveillance