Cancer type | Number (%) | Genes with clinically significant variants detected |
---|---|---|
Gastrointestinal | 271 (33.6) | APC, AXIN2, CDH1†, MLH1, MSH2, MSH6, MUTYH, PMS2 |
Breast | 260 (32.2) | ATM, BARD1, CHEK2, NBN, PALB2, TP53‡ |
Breast and ovarian | 114 (14.1) | BRCA1, BRCA2 |
Melanoma/skin | 43 (5.3) | CDKN2A, MITF, TGFBR1 (MSSE) |
Ovarian | 37 (4.6) | BRIP1, RAD51C, RAD51D |
Endocrine | 33 (4.1) | MEN1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD |
Prostate | 27 (3.3) | HOXB13 |
CNS | 11 (1.4) | NF1, NF2§, TSC1, VHL |
Others | 6 (0.7) | BAP1, RB1, SMARCB1 |
Renal | 5 (0.6) | FH, FLCN |