Fig. 1

Glucocorticoid recurrent use and risk of different subtypes of breast cancer. Associations of glucocorticoid recurrent use with breast cancer risk, compared to never/occasional use, overall and breast cancer subtype (E3N Cohort; 2004 to 2014; n = 62,512). CI, confidence interval; HR, hazard ratio, ER, oestrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2. ¹HR adjusted for age (time scale), years of schooling (baseline), alcohol intake (time-varying), body mass index (time-varying), physical activity level (baseline), age at menarche (baseline), parity and age at first birth (baseline), lifetime use of oral contraceptives (baseline), age at menopause (baseline), history of breast cancer in first degree relatives (baseline), personal history of benign breast disease (time-varying), lifetime use of menopausal hormone therapy (time-varying), self-report of a mammogram performed during the previous follow-up cycle (time-varying), number of medical consultations/visits during the preceding 6 months (time-varying), and recurrent use of proton pump inhibitors (time-varying). Categories used are those displayed in Table 1.