Table 1 Characteristics of participants, overall and according to glucocorticoid exposure at the end of follow-up
Characteristics at the end of follow-up1 | All women (n = 62,512) | Exposure at the end of follow-up | |
|---|---|---|---|
Never/occasional users (n = 45,138) | Recurrent users (n = 17,374) | ||
Sociodemographic factors | |||
Age (years), mean (SD) | 72.1 (6.7) | 71.8 (6.4) | 72.8 (6.3) |
Educational level, N (%) | |||
< High school | 6516 (11) | 4536 (10) | 1980 (11) |
From high school to 4 years higher education | 45,138 (72) | 32,771 (73) | 12,367 (71) |
At least 5 years higher education | 10,858 (17) | 7831 (17) | 3027 (18) |
Lifestyle and reproductive factors | |||
BMI (kg/m2), N (%) | |||
< 18.5 | 2626 (4) | 1978 (4) | 648 (4) |
≥ 18.5 to < 23 | 25,409 (41) | 19,037 (42) | 6372 (37) |
≥ 23 to < 25 | 13,197 (21) | 9499 (21) | 3698 (21) |
≥ 25 to < 30 | 16,139 (26) | 11,207 (25) | 4932 (28) |
≥ 30 | 5141 (8) | 3417 (8) | 1724 (10) |
Physical activity (Met-h/week), N (%) | |||
≤ 34.8 | 15,649 (25) | 11,115 (25) | 4534 (26) |
> 34.8 to ≤ 57.6 | 15,680 (25) | 11,329 (25) | 4351 (25) |
> 57.6 to ≤ 88.8 | 15,567 (25) | 11,306 (25) | 4261 (25) |
> 88.8 | 15,616 (25) | 11,388 (25) | 4228 (24) |
Smoking status, N (%) | |||
Never smoker | 33,281 (53) | 24,229 (54) | 9052 (52) |
Current smoker | 4741 (8) | 3307 (7) | 1434 (8) |
Past smoker | 24,490 (39) | 17,602 (39) | 6888 (40) |
Alcohol intake (g/day), N (%) | |||
Abstainer | 7832 (13) | 5694 (13) | 2138 (13) |
≤ 5 | 16,796 (27) | 12,198 (27) | 4598 (26) |
> 5 to ≤ 10 | 9357 (15) | 6863 (15) | 2494 (14) |
> 10 to ≤ 20 | 12,053 (19) | 8700 (19) | 3353 (19) |
> 20 | 12,522 (20) | 8957 (20) | 3565 (21) |
Missing | 3952 (6) | 2726 (6) | 1226 (7) |
Breastfeeding, N (%) | |||
Never | 23,425 (37) | 16,829 (37) | 6596 (38) |
Ever | 34,174 (55) | 24,941 (55) | 9233 (53) |
Missing | 4913 (8) | 3368 (8) | 1545 (9) |
Age at menopause (years), mean (SD) | 50.5 (3.7) | 50.6 (3.7) | 50.3 (3.9) |
Age at menarche (years), N (%) | |||
< 13 | 28,078 (45) | 20,054 (44) | 8024 (46) |
≥ 13 | 34,434 (55) | 25,084 (56) | 9350 (54) |
Parity and age at first full-term pregnancy, N (%) | |||
Nulliparous | 7282 (12) | 5346 (12) | 1936 (11) |
First child before age 30 years, one or two children | 31,393 (50) | 22,434 (50) | 8959 (51) |
First child before age 30 years, three or more children | 17,373 (28) | 12,592 (28) | 4781 (28) |
First child after age 30 years | 6464 (10) | 4766 (11) | 1698 (10) |
Lifetime oral contraceptive use, N (%) | 38,570 (62) | 27,719 (61) | 10,851 (62) |
Lifetime MHT use, N (%) | 45,239 (72) | 31,843 (71) | 13,396 (77) |
Number of medical consultations/visits during the preceding 6 months, N (%) | |||
0 | 3277 (5) | 2865 (6) | 412 (2) |
1 to 3 | 25,413 (41) | 20,289 (45) | 5124 (30) |
≥ 4 | 33,491 (54) | 21,667 (48) | 11,824 (68) |
Missing | 331 (1) | 317 (1) | 14 (0) |
Self-report of a mammogram performed during the previous follow-up cycle, N (%) | 51,097 (82) | 36,800 (82) | 14,297 (82) |
Lifetime personal history of benign breast disease, N (%) | 23,268 (37) | 16,435 (36) | 6833 (39) |
History of breast cancer in first-degree relatives, N (%) | 7139 (11) | 5196 (12) | 1943 (11) |
Comorbidities, N (%) | |||
Lifetime history of arthrosis | 21,475 (34) | 14,152 (31) | 7323 (42) |
Lifetime history of rheumatisms | 6111 (10) | 4504 (10) | 1607 (9) |
Lifetime history of arthritis | 888 (1) | 591 (1) | 297 (2) |
Lifetime history of polyarthritis | 2375 (4) | 1180 (3) | 1195 (7) |
Lifetime history of spondyloarthritis | 236 (1) | 123 (0) | 113 (1) |
Lifetime history of asthma | 6043 (10) | 3484 (8) | 2559 (15) |
Lifetime history of chronic bronchitis | 7102 (11) | 4278 (9) | 2824 (16) |
Lifetime history of hay fever | 12,633 (20) | 8629 (19) | 4004 (23) |
Lifetime history of chronic inflammatory bowel diseases | 2284 (4) | 1576 (3) | 708 (4) |
Recurrent use of other drugs2, N (%) | |||
Nonsteroidal anti-inflammatory drugs | 38,493 (62) | 14,238 (47) | 24,255 (75) |
Immunosuppressants | 895 (1) | 171 (0) | 724 (4) |
Paracetamol | 38,392 (61) | 24,725 (55) | 13,667 (79) |
Proton pump inhibitors | 30,063 (48) | 18,011 (40) | 12,052 (69) |
Anti-arthritics | 26,400 (42) | 17,095 (38) | 9305 (54) |