Characteristic | Maternal TdaP3-IPV (n = 77) | Maternal TdaP5-IPV (n = 77) | Unvaccinated mothers (n = 25) | Unvaccinated mothers from Infanrix hexa study (n = 18) |
Women | ||||
Age, years, median (range) | 34 (20–42) | 32 (21–44) | 31 (20–47) | |
Ethnicity, n (%) | ||||
White | 63 (82%) | 63 (82%) | 17 (68%) | 16 (89%) |
Asian | 6 (8%) | 7 (9%) | 2 (8%) | 1 (6%) |
Black | 3 (4%) | 3 (4%) | 5 (20%) | 0 |
Chinese | 1 (1%) | 1 (1%) | 0 | 0 |
Mixed | 3 (4%) | 3 (4%) | 1 (4%) | 1 (6%) |
Others | 1 (1%) | 0 | 0 | 0 |
Site, n (%) | ||||
Gloucestershire, UK | 3 (4%) | 5 (6%) | 0 | 5 (28%) |
Hertfordshire, UK | 33 (43%) | 28 (36%) | 3 (12%) | 3 (17%) |
South London, UK | 41 (53%) | 44 (57%) | 22 (88%) | 10 (56%) |
Median gestation at vaccination, week (range) | 29 (28–34) | 29 (28–33) | ||
Median interval from antenatal vaccination to delivery, weeks (range) | 10 (1–14) | 10 (3–14) | ||
Median interval from delivery to blood sample post-delivery, days (range) [number of samples] | 3 (0–10) [51] | 2 (0–9) [57] | ||
Maternal TdaP3-IPV (n = 70) | Maternal TdaP5-IPV (n = 74) | Unvaccinated mothers (n = 27) | Unvaccinated mothers from Infanrix hexa study (n = 19) | |
Infants | ||||
Twin, n (%) | 6 (9%) | 4 (5%) | 4 (15%) | 2 (11%) |
Female, n (%) | 33 (42%) | 38 (51%) | 13 (48%) | 10 (52%) |
Median gestation at birth, weeks (range) | 39 (31–42) | 40 (33–42) | 38.5 (34–42) | 39 (37–42) |
Median birth weight, kg (range) | 3.39 (1.54–4.69) | 3.52 (1.72–4.93) | 3.42 (2.74–4.20) | |
Cord blood collected, n (%) | 20 (29%) | 21 (28%) | ||
Infant peripheral blood collected, n (%) | 37 (53%) | 32 (43%) | ||
Median interval from birth to 1st infant blood sample, days (range) [number of samples] | 3 (0–10) [57] | 2 (0–9) [53] | ||
Median age at pre-vaccination blood sample and vaccine dose 1, days (range) [number of samples] | 60 (53–87) [62] | 62 (50–80) [70] | 64 (54–83) [27] | 58 (54–81) [19] |
Median age at vaccine dose 2, days (range) [number of samples] | 89 (81–113) [63] | 91 (81–108) [69] | 93 (82–125) [27] | 89 (82–121) [19] |
Median age at vaccine dose 3, days (range) [number of samples] | 120 (108–154) [63] | 116.5 (110–143) [68] | 123 (110–154) [27] | 122 (112–156) [19] |
Median interval to blood sample after vaccine dose 3, days (range) [number of samples] | 28 (21–47) [62] | 28 (21–55) [65] | 28 (21–52) [27] | 28 (21–40) [18] |
Median age at “1 year” vaccination, days (range) [n vaccinated] | 372 (351–404) [61] | 372 (358–413) [65] | 373 (366–394) [27] | 377 (354–395) [17] |
Median interval from “1 year” vaccination to blood sample, days (range) [number of samples] | 28 (21–48) [61] | 29 (21–42) [63] | 29 (21–52) [27] | 31 (21–51) [17] |