| |
Maternal TdaP3-IPV
|
Maternal TdaP5-IPV
|
TdaP5-IPV:TdaP3-IPV
|
TdaP5-IPV and TdaP3-IPV combined
|
|---|
|
Antigen
|
N
|
Maternal GMC (95% CI) at delivery of infant
|
N
|
Geometric mean placental transfer ratio (95% CI)
|
N
|
Maternal GMC (95% CI) at delivery of infant
|
N
|
Geometric mean placental transfer ratio (95% CI)
|
Adjusteda ratio of placental transfer ratios (95% CI)
|
Correlation coefficientb for infant vs maternal GMC
|
Fold change in GMC per week, from maternal vaccination to birtha
|
|---|
|
PT
|
51
|
37.46 (28.88–48.57)
|
51
|
1.37 (1.24–1.52)
|
57
|
23.77 (18.1–31.21)
|
52
|
1.60 (1.47–1.73)
|
1.11 (0.99–1.24)
|
0.95
|
1.08 (1.05–1.10)
|
|
FHA
|
51
|
163.96 (128.67–208.92)
|
51
|
1.47 (1.34–1.62)
|
57
|
68.86 (56.04–84.63)
|
52
|
1.51 (1.35–1.68)
|
0.95 (0.85–1.06)
|
0.93
|
1.10 (1.08–1.13)
|
|
FIM
|
51
|
22.97 (15.19–34.72)
|
51
|
1.41 (1.29–1.54)
|
57
|
195.71 (127.17–301.19)
|
52
|
1.58 (1.43–1.74)
|
1.07 (0.95–1.21)
|
0.99
|
1.06 (1.04–1.09)
|
|
PRN
|
51
|
186.06 (118.55–292.02)
|
50
|
1.37 (1.21–1.55)
|
57
|
181.38 (125.15–262.86)
|
50
|
1.40 (1.25–1.57)
|
0.95 (0.83–1.09)
|
0.96
|
1.11 (1.08–1.14)
|
- Abbreviations: TdaP3-IPV low dose diphtheria, tetanus, acellular pertussis (three pertussis antigens), inactivated poliovirus, CI confidence interval, TdaP5-IPV low dose diphtheria, tetanus, acellular pertussis (five pertussis antigens), inactivated poliovirus, PT pertussis toxin, FHA filamentous haemagglutinin, FIM fimbriae types 2 and 3, PRN pertactin, GMC geometric mean concentration
- aAdjusted for interval from maternal vaccination to birth of infant; bPearson correlation coefficient
