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Table 3 Pertussis-antigen-specific IgG GMC in mothers at delivery and placental transfer from TdaP3-IPV- and TdaP5-IPV-vaccinated mothers to their infants

From: A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants

  Maternal TdaP3-IPV Maternal TdaP5-IPV TdaP5-IPV:TdaP3-IPV TdaP5-IPV and TdaP3-IPV combined
Antigen N Maternal GMC (95% CI) at delivery of infant N Geometric mean placental transfer ratio (95% CI) N Maternal GMC (95% CI) at delivery of infant N Geometric mean placental transfer ratio (95% CI) Adjusteda ratio of placental transfer ratios (95% CI) Correlation coefficientb for infant vs maternal GMC Fold change in GMC per week, from maternal vaccination to birtha
PT 51 37.46 (28.88–48.57) 51 1.37 (1.24–1.52) 57 23.77 (18.1–31.21) 52 1.60 (1.47–1.73) 1.11 (0.99–1.24) 0.95 1.08 (1.05–1.10)
FHA 51 163.96 (128.67–208.92) 51 1.47 (1.34–1.62) 57 68.86 (56.04–84.63) 52 1.51 (1.35–1.68) 0.95 (0.85–1.06) 0.93 1.10 (1.08–1.13)
FIM 51 22.97 (15.19–34.72) 51 1.41 (1.29–1.54) 57 195.71 (127.17–301.19) 52 1.58 (1.43–1.74) 1.07 (0.95–1.21) 0.99 1.06 (1.04–1.09)
PRN 51 186.06 (118.55–292.02) 50 1.37 (1.21–1.55) 57 181.38 (125.15–262.86) 50 1.40 (1.25–1.57) 0.95 (0.83–1.09) 0.96 1.11 (1.08–1.14)
  1. Abbreviations: TdaP3-IPV low dose diphtheria, tetanus, acellular pertussis (three pertussis antigens), inactivated poliovirus, CI confidence interval, TdaP5-IPV low dose diphtheria, tetanus, acellular pertussis (five pertussis antigens), inactivated poliovirus, PT pertussis toxin, FHA filamentous haemagglutinin, FIM fimbriae types 2 and 3, PRN pertactin, GMC geometric mean concentration
  2. aAdjusted for interval from maternal vaccination to birth of infant; bPearson correlation coefficient