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Table 1 Sex-specific associations of genetically mimicked statins, PCSK9 inhibitors, and ezetimibe (based on rs12916, rs11591147, and rs10260606, respectively) with continuous phenotypes strongly associated with rs12916 (excluding some body composition traits)

From: A phenome-wide association study of genetically mimicked statins

Trait Genetically mimicked statins (rs12916) Genetically mimicked PCSK9 inhibitors (rs11591147) Genetically mimicked ezetimibe (rs10260606)
Both sexes Men Women P value** Both sexes Male Women P value** Both sexes Male Women P value**
Beta* Pval Beta* Pval Beta* Pval Beta* Pval Beta* Pval Beta* Pval Beta* Pval Beta* Pval Beta* Pval
ApoB −0.89 1.02 × 10−112 −0.88 4.03 × 10−38 −0.89 2.49 × 10−79 0.001 −0.99 9.88 × 10−324 −1.01 5.71 × 10−151 −0.97 7.14 × 10−176 0.84 −0.90 5.47 × 10−25 −0.87 1.70 × 10−8 −0.91 4.43 × 10−19 0.06
LDL-c −1.00 4.32 × 10−144 −1.00 2.45 × 10−49 −1.00 3.25 × 10−100 <0.001 −1.00 0 −1.00 1.18 × 10−150 −1.00 5.02 × 10−189 0.55 −1.00 4.33 × 10−31 −1.00 6.92 × 10−11 −1.00 8.49 × 10−23 0.07
TC −0.95 9.66 × 10−134 −0.97 1.67 × 10−46 −0.95 1.40 × 10−92 0.002 −0.90 6.07 × 10−278 −0.91 3.18 × 10−124 −0.90 1.19 × 10−157 0.63 −0.90 2.53 × 10−26 −0.91 3.16 × 10−9 −0.91 1.72 × 10−19 0.09
HbA1c 0.19 4.30 × 10−7 0.20 2.65 × 10−03 0.19 3.66 × 10−05 0.61 −0.06 0.013 −0.10 0.011 −0.03 0.329 0.21 0.47 3.12 × 10−8 0.41 0.007 0.51 2.32 × 10−7 0.15
Calcium −0.22 1.27 × 10−7 −0.15 0.039 −0.26 1.64 × 10−07 0.04 −0.01 0.755 −0.02 0.560 0.003 0.935 0.63 0.08 0.401 0.27 0.090 −0.04 0.705 0.13
SHBG −0.17 5.68 × 10−6 −0.09 0.189 −0.25 1.15 × 10−06 0.01 0.003 0.893 0.05 0.204 −0.03 0.401 0.14 0.01 0.954 0.06 0.685 −0.05 0.678 0.56
BMR 0.19 5.30 × 10−19 0.26 1.01 × 10−4 0.29 7.01 × 10−10 0.17 −0.01 0.977 −0.03 0.395 0.02 0.637 0.35 −0.02 0.661 0.23 0.120 −0.09 0.367 0.08
MPV 0.21 1.94 × 10−07 0.26 9.97 × 10−5 0.17 5.25 × 10−4 0.62 −0.05 0.068 −0.09 0.022 −0.01 0.746 0.14 −0.44 6.21 × 10−7 −0.71 3.70 × 10−6 −0.26 0.013 0.09
Platelet count −0.26 7.03 × 10−12 −0.37 3.34 × 10−8 −0.20 1.89 × 10−5 0.26 0.05 0.040 0.07 0.071 0.04 0.267 0.58 0.21 0.014 0.32 0.039 0.16 0.128 0.64
Platelet crit −0.18 1.27 × 10−6 −0.28 4.30 × 10−5 −0.14 4.17 × 10−3 0.30 0.03 0.152 0.03 0.471 0.04 0.216 0.75 0.01 0.921 −0.04 0.806 0.02 0.865 0.77
BMI 0.32 5.20 × 10−24 0.33 6.11 × 10−7 0.31 3.73 × 10−11 0.41 0.02 0.894 0.03 0.418 −0.02 0.636 0.36 0.05 0.587 0.15 0.317 −0.14 0.178 0.10
Weight 0.27 1.40 × 10−22 0.31 3.07 × 10−6 0.30 1.15 × 10−10 0.33 0.01 0.913 0.03 0.460 −0.03 0.406 0.27 0.01 0.915 0.20 0.198 −0.10 0.321 0.11
HC 0.31 1.30 × 10−21 0.35 1.90 × 10−7 0.28 5.20 × 10−9 0.88 0.02 0.542 0.01 0.768 0.02 0.535 0.84 0.08 0.366 0.09 0.545 −0.15 0.135 0.14
WC 0.24 2.10 × 10−16 0.29 1.71 × 10−5 0.26 2.33 × 10−8 0.52 0.05 0.088 0.01 0.764 0.06 0.067 0.31 0.02 0.773 0.07 0.657 −0.05 0.610 0.50
  1. *Relative effect on LDL-c, i.e., the sex-specific effect size for each trait divided by the absolute value of the corresponding sex-specific effect size for LDL-c
  2. **P value for Z test
  3. HC hip circumference, WC waist circumference