Table 1 Sex-specific associations of genetically mimicked statins, PCSK9 inhibitors, and ezetimibe (based on rs12916, rs11591147, and rs10260606, respectively) with continuous phenotypes strongly associated with rs12916 (excluding some body composition traits)
From: A phenome-wide association study of genetically mimicked statins
Trait | Genetically mimicked statins (rs12916) | Genetically mimicked PCSK9 inhibitors (rs11591147) | Genetically mimicked ezetimibe (rs10260606) | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Both sexes | Men | Women | P value** | Both sexes | Male | Women | P value** | Both sexes | Male | Women | P value** | ||||||||||
Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | Beta* | Pval | ||||
ApoB | −0.89 | 1.02 × 10−112 | −0.88 | 4.03 × 10−38 | −0.89 | 2.49 × 10−79 | 0.001 | −0.99 | 9.88 × 10−324 | −1.01 | 5.71 × 10−151 | −0.97 | 7.14 × 10−176 | 0.84 | −0.90 | 5.47 × 10−25 | −0.87 | 1.70 × 10−8 | −0.91 | 4.43 × 10−19 | 0.06 |
LDL-c | −1.00 | 4.32 × 10−144 | −1.00 | 2.45 × 10−49 | −1.00 | 3.25 × 10−100 | <0.001 | −1.00 | 0 | −1.00 | 1.18 × 10−150 | −1.00 | 5.02 × 10−189 | 0.55 | −1.00 | 4.33 × 10−31 | −1.00 | 6.92 × 10−11 | −1.00 | 8.49 × 10−23 | 0.07 |
TC | −0.95 | 9.66 × 10−134 | −0.97 | 1.67 × 10−46 | −0.95 | 1.40 × 10−92 | 0.002 | −0.90 | 6.07 × 10−278 | −0.91 | 3.18 × 10−124 | −0.90 | 1.19 × 10−157 | 0.63 | −0.90 | 2.53 × 10−26 | −0.91 | 3.16 × 10−9 | −0.91 | 1.72 × 10−19 | 0.09 |
HbA1c | 0.19 | 4.30 × 10−7 | 0.20 | 2.65 × 10−03 | 0.19 | 3.66 × 10−05 | 0.61 | −0.06 | 0.013 | −0.10 | 0.011 | −0.03 | 0.329 | 0.21 | 0.47 | 3.12 × 10−8 | 0.41 | 0.007 | 0.51 | 2.32 × 10−7 | 0.15 |
Calcium | −0.22 | 1.27 × 10−7 | −0.15 | 0.039 | −0.26 | 1.64 × 10−07 | 0.04 | −0.01 | 0.755 | −0.02 | 0.560 | 0.003 | 0.935 | 0.63 | 0.08 | 0.401 | 0.27 | 0.090 | −0.04 | 0.705 | 0.13 |
SHBG | −0.17 | 5.68 × 10−6 | −0.09 | 0.189 | −0.25 | 1.15 × 10−06 | 0.01 | 0.003 | 0.893 | 0.05 | 0.204 | −0.03 | 0.401 | 0.14 | 0.01 | 0.954 | 0.06 | 0.685 | −0.05 | 0.678 | 0.56 |
BMR | 0.19 | 5.30 × 10−19 | 0.26 | 1.01 × 10−4 | 0.29 | 7.01 × 10−10 | 0.17 | −0.01 | 0.977 | −0.03 | 0.395 | 0.02 | 0.637 | 0.35 | −0.02 | 0.661 | 0.23 | 0.120 | −0.09 | 0.367 | 0.08 |
MPV | 0.21 | 1.94 × 10−07 | 0.26 | 9.97 × 10−5 | 0.17 | 5.25 × 10−4 | 0.62 | −0.05 | 0.068 | −0.09 | 0.022 | −0.01 | 0.746 | 0.14 | −0.44 | 6.21 × 10−7 | −0.71 | 3.70 × 10−6 | −0.26 | 0.013 | 0.09 |
Platelet count | −0.26 | 7.03 × 10−12 | −0.37 | 3.34 × 10−8 | −0.20 | 1.89 × 10−5 | 0.26 | 0.05 | 0.040 | 0.07 | 0.071 | 0.04 | 0.267 | 0.58 | 0.21 | 0.014 | 0.32 | 0.039 | 0.16 | 0.128 | 0.64 |
Platelet crit | −0.18 | 1.27 × 10−6 | −0.28 | 4.30 × 10−5 | −0.14 | 4.17 × 10−3 | 0.30 | 0.03 | 0.152 | 0.03 | 0.471 | 0.04 | 0.216 | 0.75 | 0.01 | 0.921 | −0.04 | 0.806 | 0.02 | 0.865 | 0.77 |
BMI | 0.32 | 5.20 × 10−24 | 0.33 | 6.11 × 10−7 | 0.31 | 3.73 × 10−11 | 0.41 | 0.02 | 0.894 | 0.03 | 0.418 | −0.02 | 0.636 | 0.36 | 0.05 | 0.587 | 0.15 | 0.317 | −0.14 | 0.178 | 0.10 |
Weight | 0.27 | 1.40 × 10−22 | 0.31 | 3.07 × 10−6 | 0.30 | 1.15 × 10−10 | 0.33 | 0.01 | 0.913 | 0.03 | 0.460 | −0.03 | 0.406 | 0.27 | 0.01 | 0.915 | 0.20 | 0.198 | −0.10 | 0.321 | 0.11 |
HC | 0.31 | 1.30 × 10−21 | 0.35 | 1.90 × 10−7 | 0.28 | 5.20 × 10−9 | 0.88 | 0.02 | 0.542 | 0.01 | 0.768 | 0.02 | 0.535 | 0.84 | 0.08 | 0.366 | 0.09 | 0.545 | −0.15 | 0.135 | 0.14 |
WC | 0.24 | 2.10 × 10−16 | 0.29 | 1.71 × 10−5 | 0.26 | 2.33 × 10−8 | 0.52 | 0.05 | 0.088 | 0.01 | 0.764 | 0.06 | 0.067 | 0.31 | 0.02 | 0.773 | 0.07 | 0.657 | −0.05 | 0.610 | 0.50 |