Ischemic stroke | Hemorrhagic stroke | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
HR (95%CI) | HR (95%CI) | |||||||||
LDL-C, mmol/L | ≤40 | 40–55 | 55–70 | ≤40 | 40–55 | 55–70 | ||||
Number | 982 | 2374 | 5971 | 982 | 2374 | 5971 | ||||
Case/person-years | 90/8034 | 110/21,570 | 188/56,249 | 42/8341 | 34/21,846 | 69/56,725 | ||||
Mean LDL-C ± SD, mg/dL | 26.7 ± 10.3 | 49.1 ± 4.05 | 63.0 ± 4.10 | 26.7 ± 10.3 | 49.1 ± 4.05 | 63.0 ± 4.10 | ||||
Multivariate modela | 2.07 (1.53, 2.80) | 1.43 (1.11, 1.84) | 1.00 (reference) | 2.70 (1.70, 4.30) | 1.16 (0.74, 1.80) | 1.00 (reference) | ||||
Excluding eGFR < 60 ml/min/1.73 m2 | 2.21 (1.60, 3.07) | 1.53 (1.17, 2.00) | 1.00 (reference) | 2.65 (1.63, 4.30) | 1.13 (0.72, 1.77) | 1.00 (reference) | ||||
Excluding Framingham risk score > 30% | 2.37 (1.57, 3.58) | 1.48 (1.04, 2.10) | 1.00 (reference) | 2.60 (1.39, 4.86) | 1.00 (0.53, 1.88) | 1.00 (reference) | ||||
Excluding BMI < 18.5 kg/m2 | 2.09 (1.54, 2.84) | 1.45 (1.13, 1.87) | 1.00 (reference) | 2.69 (1.68, 4.31) | 1.19 (0.76, 1.85) | 1.00 (reference) | ||||
Excluding blood pressure-lowering drugs | 2.01 (1.41, 2.88) | 1.40 (1.03, 1.91) | 1.00 (reference) | 2.56 (1.49, 4.40) | 0.92 (0.53, 1.62) | 1.00 (reference) | ||||
Excluding glucose-lowering drugs | 2.02 (1.48, 2.76) | 1.45 (1.12, 1.88) | 1.00 (reference) | 2.70 (1.68, 4.33) | 1.08 (0.69, 1.71) | 1.00 (reference) | ||||
Quartiles of LDL-C | Q1 | Q2 | Q3 | Q4 | Ptrendb | Q1 | Q2 | Q3 | Q4 | Ptrend |
Number | 2343 | 2333 | 2327 | 2324 | 2343 | 2333 | 2327 | 2324 | ||
Case/person-years | 153/20,356 | 108/21,562 | 72/21,893 | 55/22,040 | 60/20,800 | 40/21,824 | 23/22,088 | 22/22,199 | ||
Mean LDL-C ± SD, mg/dL | 38.1 ± 12.0 | 55.3 ± 2.43 | 62.1 ± 1.59 | 67.2 ± 1.38 | 38.1 ± 12.0 | 55.3 ± 2.43 | 62.1 ± 1.59 | 67.2 ± 1.38 | ||
Multivariate modela | 2.39 (1.69, 3.39) | 2.40 (1.69, 3.41) | 1.48 (1.02, 2.16) | 1.00 (reference) | < 0.001 | 2.14 (1.24, 3.69) | 1.89 (1.08, 3.31) | 1.13 (0.61, 2.11) | 1.00 (reference) | 0.002 |
Excluding eGFR < 60 ml/min/1.73 m2 | 2.76 (1.89, 4.03) | 2.68 (1.84, 3.92) | 1.61 (1.07, 2.42) | 1.00 (reference) | < 0.001 | 2.11 (1.20, 3.72) | 1.87 (1.05, 3.32) | 1.20 (0.64, 2.25) | 1.00 (reference) | 0.004 |
Excluding Framingham risk score > 30% | 2.67 (1.63, 4.40) | 2.62 (1.59, 4.30) | 1.58 (0.93, 2.69) | 1.00 (reference) | < 0.001 | 2.34 (1.07, 5.13) | 1.99 (0.89, 4.46) | 1.53 (0.66, 3.55) | 1.00 (reference) | 0.032 |
Excluding BMI < 18.5 kg/m2 | 2.40 (1.70, 3.41) | 2.41 (1.70, 3.42) | 1.47 (1.01, 2.15) | 1.00 (reference) | < 0.001 | 2.13 (1.23, 3.68) | 1.92 (1.10, 3.37) | 1.09 (0.58, 2.05) | 1.00 (reference) | 0.002 |
Excluding blood pressure-lowering drugs | 2.38 (1.56, 3.63) | 2.32 (1.51, 3.55) | 1.53 (0.97, 2.41) | 1.00 (reference) | < 0.001 | 2.01 (1.04, 3.87) | 1.68 (0.85, 3.33) | 1.05 (0.49, 2.23) | 1.00 (reference) | 0.013 |
Excluding glucose-lowering drugs | 2.37 (1.65, 3.39) | 2.36 (1.64, 3.38) | 1.39 (0.94, 2.05) | 1.00 (reference) | < 0.001 | 2.15 (1.23, 3.75) | 1.79 (1.00, 3.19) | 1.18 (0.63, 2.21) | 1.00 (reference) | 0.002 |