Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

Table 1 Cohort participant characteristics and distribution of explanatory variables, by rotavirus vaccination status

Variable		Overall		No rotavirus vaccination		Rotavirus vaccination		P value^a
		N	%	n	%	n	%
Total participants		880,629		537,516		343,113
Sex	Male	450,956	51.2	275,336	51.2	175,620	51.2	0.719
	Female	429,673	48.8	262,180	48.8	167,493	48.8
Year of birth	2010	162,510	18.5	161,049	30.0	1461	0.4	< 0.001
	2011	158,273	18.0	156,413	29.1	1860	0.5
	2012	154,619	17.6	152,182	28.3	2437	0.7
	2013	142,384	16.2	50,625	9.4	91,759	26.7
	2014	135,007	15.3	9726	1.8	125,281	36.5
	2015	127,836	14.5	7521	1.4	120,315	35.1
Region	North East	34,011	3.9	20,654	3.8	13,357	3.9	< 0.001
	North West	130,546	14.8	79,505	14.8	51,041	14.9
	Yorkshire and Humber	31,402	3.6	19,359	3.6	12,043	3.5
	East Midlands	21,895	2.5	13,548	2.5	8347	2.4
	West Midlands	146,977	16.7	89,481	16.7	57,496	16.8
	East of England	50,765	5.8	30,517	5.7	20,248	5.9
	South West	110,315	12.5	67,537	12.6	42,778	12.5
	South Central	109,198	12.4	66,514	12.4	42,684	12.4
	London	180,914	20.6	111,218	20.7	69,696	20.3
	South East Coast	64,231	7.3	38,920	7.2	25,311	7.4
IMD quintile	1	173,439	19.7	104,602	19.5	68,837	20.1	< 0.001
	2	158,821	18.1	95,364	17.8	63,457	18.5
	3	161,999	18.4	98,331	18.3	63,668	18.6
	4	182,182	20.7	111,907	20.8	70,275	20.5
	5	203,415	23.1	126,859	23.6	76,556	22.3
T1D record	No	879,896	99.9	537,027	99.9	342,869	99.9	0.001
	Yes	733	0.1	493	0.1	240	0.1
CD record	No	878,972	99.8	536,380	99.9	342,592	99.9	< 0.001
	Yes	1657	0.2	1136	0.2	521	0.2
		Mean	SD	Mean	SD	Mean	SD
GP consultations per year		7.29	4.96	7.08	5.02	7.63	4.84	< 0.001
Person-days at-risk		1843	773	2015	809	1577	624	< 0.001

SD standard deviation
^aComparing the distribution of participants within a variable between vaccinated and unvaccinated

ISSN: 1741-7015