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Table 2 Results from mixed-effects Cox regression models, with random intercepts for GP practices

From: Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

   CD T1D
Variable   Univariable Adjusted Univariable Adjusted
   HR 95% CI HR 95% CI HR 95% CI HR 95% CI
Rotavirus vaccination No ref ref ref ref ref ref ref ref
  Yes 0.93 0.84–1.04 1.05 0.86–1.28 1.01 0.87–1.19 0.89 0.68–1.19
Sex Male ref ref ref ref Ref ref ref ref
  Female 1.42 1.29–1.56 1.42 1.29–1.56 1.02 0.88–1.17 1.02 0.88–1.17
Year of birth 2010 ref ref ref Ref ref ref ref ref
  2011 0.98 0.85–1.14 0.98 0.85–1.14 1.08 0.86–1.34 1.08 0.86–1.34
  2012 1.03 0.89–1.19 1.03 0.89–1.19 0.93 0.74–1.17 0.93 0.74–1.17
  2013 0.91 0.77–1.06 0.88 0.72–1.08 1.11 0.88–1.41 1.19 0.89–1.58
  2014 0.95 0.80–1.13 0.91 0.71–1.17 1.15 0.90–1.48 1.28 0.89–1.82
  2015 0.84 0.70–1.02 0.81 0.6–1.02 0.89 0.65–1.19 0.98 0.66–1.46
Region North East ref ref ref ref Ref Ref ref Ref
  North West 1.18 0.85–1.63 1.12 0.82–1.54 0.81 0.55–1.18
  Yorkshire and Humber 1.45 0.97–2.15 1.39 0.95–2.04 0.61 0.35–1.06
  East Midlands 1.07 0.68–1.70 0.96 0.61–1.50 0.91 0.52–1.57
  West Midlands 1.18 0.86–1.62 1.10 0.80–1.51 0.66 0.45–0.97
  East of England 1.23 0.85–1.78 1.01 0.70–1.45 1.08 0.70–1.66
  South West 1.25 0.90–1.74 1.13 0.82–1.56 0.83 0.56–1.23
  South Central 1.40 1.01–1.94 1.14 0.83–1.58 0.77 0.52–1.15
  London 1.06 0.77–1.46 1.02 0.74–1.40 0.63 0.43–0.92
  South East Coast 1.31 0.93–1.86 1.11 0.79–1.57 0.94 0.62–1.43
IMD quintile 1 ref ref ref ref ref Ref ref Ref
  2 0.96 0.84–1.11 0.97 0.84–1.12 1.20 0.96–1.51 1.20 0.96–1.51
  3 0.86 0.75–1.00 0.87 0.75–1.02 1.05 0.83–1.33 1.05 0.83–1.33
  4 0.72 0.61–0.84 0.73 0.62–0.85 1.10 0.87–1.38 1.10 0.87–1.39
  5 0.58 0.50–0.68 0.58 0.49–0.69 1.02 0.81–1.29 1.02 0.81–1.29
GP consultations per year   1.24 1.24–1.25 1.25 1.24–1.25