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Table 2 Results from mixed-effects Cox regression models, with random intercepts for GP practices

From: Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

  

CD

T1D

Variable

 

Univariable

Adjusted

Univariable

Adjusted

  

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

Rotavirus vaccination

No

ref

ref

ref

ref

ref

ref

ref

ref

 

Yes

0.93

0.84–1.04

1.05

0.86–1.28

1.01

0.87–1.19

0.89

0.68–1.19

Sex

Male

ref

ref

ref

ref

Ref

ref

ref

ref

 

Female

1.42

1.29–1.56

1.42

1.29–1.56

1.02

0.88–1.17

1.02

0.88–1.17

Year of birth

2010

ref

ref

ref

Ref

ref

ref

ref

ref

 

2011

0.98

0.85–1.14

0.98

0.85–1.14

1.08

0.86–1.34

1.08

0.86–1.34

 

2012

1.03

0.89–1.19

1.03

0.89–1.19

0.93

0.74–1.17

0.93

0.74–1.17

 

2013

0.91

0.77–1.06

0.88

0.72–1.08

1.11

0.88–1.41

1.19

0.89–1.58

 

2014

0.95

0.80–1.13

0.91

0.71–1.17

1.15

0.90–1.48

1.28

0.89–1.82

 

2015

0.84

0.70–1.02

0.81

0.6–1.02

0.89

0.65–1.19

0.98

0.66–1.46

Region

North East

ref

ref

ref

ref

Ref

Ref

ref

Ref

 

North West

1.18

0.85–1.63

1.12

0.82–1.54

0.81

0.55–1.18

–

–

 

Yorkshire and Humber

1.45

0.97–2.15

1.39

0.95–2.04

0.61

0.35–1.06

–

–

 

East Midlands

1.07

0.68–1.70

0.96

0.61–1.50

0.91

0.52–1.57

–

–

 

West Midlands

1.18

0.86–1.62

1.10

0.80–1.51

0.66

0.45–0.97

–

–

 

East of England

1.23

0.85–1.78

1.01

0.70–1.45

1.08

0.70–1.66

–

–

 

South West

1.25

0.90–1.74

1.13

0.82–1.56

0.83

0.56–1.23

–

–

 

South Central

1.40

1.01–1.94

1.14

0.83–1.58

0.77

0.52–1.15

–

–

 

London

1.06

0.77–1.46

1.02

0.74–1.40

0.63

0.43–0.92

–

–

 

South East Coast

1.31

0.93–1.86

1.11

0.79–1.57

0.94

0.62–1.43

–

–

IMD quintile

1

ref

ref

ref

ref

ref

Ref

ref

Ref

 

2

0.96

0.84–1.11

0.97

0.84–1.12

1.20

0.96–1.51

1.20

0.96–1.51

 

3

0.86

0.75–1.00

0.87

0.75–1.02

1.05

0.83–1.33

1.05

0.83–1.33

 

4

0.72

0.61–0.84

0.73

0.62–0.85

1.10

0.87–1.38

1.10

0.87–1.39

 

5

0.58

0.50–0.68

0.58

0.49–0.69

1.02

0.81–1.29

1.02

0.81–1.29

GP consultations per year

 

1.24

1.24–1.25

–

–

1.25

1.24–1.25

–

–