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Table 3 Rate ratios for severe COVID-19 associated with risk conditions (with severe respiratory disease as reference category) in those eligible for shielding and not resident in care homes

From: Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

    Univariate Multivariable
  Controls (7808) Cases (1640) Rate ratio (95% CI) p-value Rate ratio (95% CI) p-value
Shielding eligibility category
Severe respiratory 3834 (49%) 744 (45%)   .   .
Solid organ transplant 112 (1%) 60 (4%) 1.58 (0.90, 2.77) 0.1 1.36 (0.70, 2.63) 0.4
Specific cancers 925 (12%) 240 (15%) 1.28 (0.98, 1.66) 0.07 0.88 (0.64, 1.21) 0.4
Rare diseases 348 (4%) 72 (4%) 1.18 (0.75, 1.84) 0.5 1.14 (0.68, 1.91) 0.6
On immunosuppressants 759 (10%) 129 (8%) 0.74 (0.53, 1.03) 0.07 0.82 (0.56, 1.20) 0.3
Additional conditions 1830 (23%) 395 (24%) 1.19 (0.95, 1.49) 0.1 1.00 (0.77, 1.31) 1
At least one child under 5 66 (1%) 27 (2%) 0.80 (0.32, 2.02) 0.6 0.45 (0.15, 1.31) 0.1
School-age children in household
0 school age 7537 (97%) 1545 (94%)   .   .
1 school age 82 (1%) 19 (1%) 0.36 (0.13, 0.99) 0.05 0.84 (0.29, 2.45) 0.7
2 or more 189 (2%) 76 (5%) 1.03 (0.60, 1.76) 0.9 0.74 (0.40, 1.37) 0.3
Adults in household
1 adult 5811 (75%) 1010 (62%)   .   .
2 adults 1647 (21%) 458 (28%) 1.60 (1.30, 1.97) <0.001 1.74 (1.37, 2.21) <0.001
3 or more 339 (4%) 167 (10%) 2.15 (1.51, 3.07) <0.001 2.52 (1.66, 3.82) <0.001
SIMD quintile (integer) 2 (1–4) 2 (1–4) 0.97 (0.91, 1.05) 0.5 0.98 (0.90, 1.06) 0.6
Recent hospital visit/stay 840 (11%) 739 (45%) 5.8 (4.6, 7.4) <0.001 6.0 (4.7, 7.7) <0.001
  1. Severe COVID-19 is defined by entry to critical care or fatal outcome
  2. Percentages are column percentages for each variable
  3. Rate ratios are from conditional logistic regression models matched for age, sex and general practice
  4. Univariate rate ratios are for models with a single covariate
  5. Multivariable rate ratios are for a model including all covariates shown in the table