Table 1 Hazard ratio (95% confidence intervals) of the studied outcomes with quartiles of FEV1 and FVC decline

 Cardiovascular events

Non-adjusted

1.95 (1.74, 2.19)

2.42 (2.16, 2.71)

1.67 (1.48, 1.88)

Reference

Adjusted

1.33 (1.19, 1.49)

1.30 (1.16, 1.46)

1.07 (0.95, 1.21)

Reference

 Coronary heart disease

Non-adjusted

2.05 (1.72, 2.44)

2.05 (1.71, 2.45)

1.67 (1.39, 2.00)

Reference

Adjusted

1.38 (1.16, 1.65)

1.08 (0.90, 1.29)

1.04 (0.86, 1.26)

Reference

 Chronic heart failure

Non-adjusted

2.02 (1.72, 2.36)

2.53 (2.17, 2.96)

1.98 (1.69, 2.33)

Reference

Adjusted

1.47 (1.25, 1.73)

1.39 (1.19, 1.63)

1.33 (1.13, 1.56)

Reference

 Stroke

Non-adjusted

1.94 (1.60, 2.36)

2.49 (2.06, 3.01)

1.65 (1.35, 2.02)

Reference

Adjusted

1.35 (1.11, 1.64)

1.34 (1.10, 1.62)

1.08 (0.88, 1.33)

Reference

 Cardiovascular events

Non-adjusted

2.72 (2.43, 3.04)

2.21 (1.97, 2.47)

1.47 (1.31, 1.66)

Reference

Adjusted

1.28 (1.14, 1.44)

1.15 (1.02, 1.30)

1.06 (0.94, 1.20)

Reference

 Coronary heart disease

Non-adjusted

2.89 (2.41, 3.46)

2.42 (2.01, 2.90)

1.74 (1.44, 2.10)

Reference

Adjusted

1.45 (1.20, 1.75)

1.33 (1.10, 1.61)

1.25 (1.03, 1.51)

Reference

 Chronic heart failure

Non-adjusted

3.22 (2.77, 3.75)

2.45 (2.10, 2.86)

1.43 (1.21, 1.69)

Reference

Adjusted

1.35 (1.15, 1.58)

1.21 (1.03, 1.42)

1.03 (0.87, 1.22)

Reference

 Stroke

Non-adjusted

2.67 (2.22, 3.22)

2.23 (1.85, 2.69)

1.25 (1.02, 1.53)

Reference

Adjusted

1.28 (1.06, 1.56)

1.19 (0.98, 1.45)

0.94 (0.77, 1.16)

Reference