The effects of increased dose of hepatitis B vaccine on mother-to-child transmission and immune response for infants born to mothers with chronic hepatitis B infection: a prospective, multicenter, large-sample cohort study

Table 1 Main characteristics of HBsAg-positive mothers and their babies from two different dose of HB vaccine

Variables	10 μg (n = 478)	20 μg (n = 477)	P value
Maternal data
Age (years)	27.3 ± 4.5	26.8 ± 4.6	0.076
HBeAg positive	154 (32.2%)	270 (55.0%)	< 0.001
HBV DNA (log₁₀ IU/mL)	2.6 ± 2.9	3.5 ± 3.2	< 0.001
HBV DNA ≥ 5 (log₁₀ IU/mL)	128	226	< 0.001
ALT (IU/L)	15.2 ± 8.6	15.6 ± 13.4	0.593
TBIL (μmol/L)	9.9 ± 6.5	9.3 ± 4.0	0.161
Infant data at birth
Sex (male)	264	270	0.669
Gestation days	277.0 ± 6.9	278.4 ± 7.3	0.450
Birth mode (vaginal delivery)	184 (38.4%)	210 (44.0%)	0.083
Birth weight (g)	3625 ± 349.0	3508 ± 380.1	0.150
1-min APGAR	9.6 ± 0.1	9.5 ± 0.2	0.140

Abbreviations: ALT alanine aminotransferase, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HBV hepatitis B virus, TBIL total bilirubin

ISSN: 1741-7015