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Table 3 The response differences to HB vaccine in infants born to HBsAg-positive mothers in two groups

From: The effects of increased dose of hepatitis B vaccine on mother-to-child transmission and immune response for infants born to mothers with chronic hepatitis B infection: a prospective, multicenter, large-sample cohort study

Infant response

Maternal HBV DNA < 5 log10 IU/mL

 

Maternal HBV DNA ≥ 5 log10 IU/mL

 

10 μg

(n = 350)

20 μg

(n = 251)

P value

10 μg

(n = 128)

20 μg

(n = 226)

P value

Failure

0 (0%)

1 (0.4%)

0.418

5 (3.9%)

7 (3.1%)

0.922

Non-responder

11 (3.1%)

5 (2.0%)

0.387

6 (4.7%)

2 (0.9%)

0.052

Low-responder

67 (19.1%)

25 (10.0%)

0.002

17 (13.3%)

24 (10.6%)

0.452

Middle-responder

192 (54.9%)

114 (45.4%)

0.022

62 (48.4%)

124 (54.9%)

0.244

High-responder

80 (22.9%)

106 (42.2%)

< 0.001

38 (29.7%)

69 (30.5%)

0.868

  1. Abbreviations: HB hepatitis B, HBsAg hepatitis B surface antigen