Table 2 Pleiotropy and heterogeneity analyses for the association between exposures and Alzheimer's disease in primary analysis

 Atrial fibrillation and flutter

0.87

0.82

0.89

-

-

 Coronary atherosclerosis

0.11

0.08

0.16

-

-

 Cardiac arrhythmias, COPD co-morbidities

0.81

0.33

0.80

-

-

 Ischemic heart disease

1.66 × 10⁻³⁷

0.46

< 0.001

0.74 (0.47, 1.15)

7.70 × 10⁻⁰⁶

 Angina (self-reported)

0.46

0.12

0.52

-

-

 Angina (diagnosed)

0.54

0.07

0.55

-

-

 Hypertension (self-reported)

1.11 × 10⁻⁰⁴

0.32

< 0.001

-

-

 Hypertension (diagnosed)

5.55 × 10⁻⁰⁵

0.73

< 0.001

-

-

 Diseases of the circulatory system

0.49

0.11

0.56

-

-

 High cholesterol (self-reported)

1.92 × 10⁻⁰⁷

0.32

< 0.001

0.79 (0.62, 1.01)

5.16 × 10⁻⁰⁵

 Diabetes (self-reported)

0.28

0.36

0.29

-

-

 Diabetes (diagnosed)

0.24

0.07

0.25

-

-

 Malignant neoplasm of prostate

0.35

0.29

0.35

-

-

 Venous thromboembolism

0.19

0.35

0.31

-

-

 DVT of lower extremities

0.48

0.34

0.53

-

-

 DVT of lower extremities and pulmonary embolism

0.26

0.38

0.35

-

-

 No vascular/heart problems

2.01 × 10⁻⁰⁴

0.34

0.001

1.53 (1.45, 1.62)

1.43 × 10⁻¹⁵

 Systolic blood pressure

2.16 × 10⁻⁰⁸

0.72

< 0.001

0.54 (0.44, 0.66)

3.10 × 10⁻⁰⁸

 Diastolic blood pressure

1.06 × 10⁻⁰⁴

0.39

< 0.001

0.55 (0.45, 0.67)

1.39 × 10⁻⁰⁸

 Arm fat mass (right)

0.09

0.17

0.09

-

-

 Arm fat percentage (left)

0.002

0.61

0.002

0.65 (0.53, 0.8)

4.99 × 10⁻⁰⁵

 Arm fat percentage (right)

0.005

0.87

0.005

0.64 (0.52, 0.78)

1.42 × 10⁻⁰⁵

 Leg fat mass (right)

0.11

0.14

0.13

-

-

 Leg fat mass (left)

0.03

0.06

0.03

0.67 (0.57, 0.8)

8.71 × 10⁻⁰⁶

 Leg fat percentage (right)

2.94 × 10⁻²⁸

0.64

< 0.001

0.51 (0.4, 0.65)

8.76 ×10⁻⁰⁸

 Leg fat percentage (left)

4.36 × 10⁻²³

0.48

< 0.001

0.53 (0.43, 0.67)

1.15 × 10⁻⁰⁷

 Trunk fat mass

0.01

0.51

0.02

0.78 (0.68, 0.9)

4.58 × 10⁻⁰⁴

 Whole body fat mass

0.10

0.22

0.11

-

-

 Waist circumference

2.90 × 10⁻⁰⁵

0.99

< 0.001

0.7 (0.58, 0.84)

1.83 × 10⁻⁰⁴

 Body mass index: by impedance measurement

3.11 × 10⁻⁰⁹

0.60

< 0.001

0.69 (0.6, 0.79)

8.48 × 10⁻⁰⁸

 Body mass index: by height and weight measurement

6.25 × 10⁻⁰⁸

0.60

< 0.001

0.72 (0.63, 0.82)

1.06 × 10⁻⁰⁶

 Father with AD/dementia

0.41

0.89

-

-

-

 Mather with AD/dementia

0.18

0.15

0.40

-

-

 Father with heart disease

0.006

0.24

0.01

0.5 (0.35, 0.72)

2.47 × 10⁻⁰⁴

 Siblings with heart disease

0.25

0.85

-

-

-

 Siblings with high blood pressure

0.02

0.64

0.02

0.65 (0.3, 1.41)

0.016

 Siblings with none of group 1 disease*

0.18

0.31

0.30

-

-

 Aspirin

0.46

0.24

0.59

-

-

 Atorvastatin

2.15 × 10⁻³³

0.36

< 0.001

0.72 (0.41, 1.26)

8.30 × 10⁻⁰⁷

 Amlodipine

0.04

0.72

0.05

-

-

 Metformin

0.70

0.48

0.70

-

-

 Simvastatin

3.75 × 10⁻⁰⁷

0.67

< 0.001

0.63 (0.42, 0.93)

1.19 × 10⁻⁰⁵

 Bendroflumethiazide

0.18

0.11

0.21

-

-

 Blood pressure medication (females)

0.02

0.50

0.03

-

-

 Blood pressure medication (males)

0.04

0.86

0.04

-

-

 Cholesterol lowering medication (females)

1.55 × 10⁻⁰⁶

0.87

< 0.001

0.71 (0.56, 0.91)

9.32 × 10⁻⁰⁶

 Cholesterol lowering medication (males)

1.70 × 10⁻⁰⁵

0.66

< 0.001

0.71 (0.62, 0.82)

3.07 × 10⁻⁰⁶

 None of medication taken (females)

0.010

0.70

0.01

1.62 (1.31, 2)

3.05 × 10⁻⁰⁵

 None of medication taken (males)

0.002

0.80

0.002

1.61 (1.43, 1.81)

4.23 × 10⁻⁰⁸

 Comparative height size at age 10

0.004

0.62

0.006

0.78 (0.66, 0.93)

0.006

 College or university degree

2.17 × 10⁻⁰⁴

0.84

< 0.001

1.2 (1.07, 1.35)

2.03 × 10⁻⁰⁴

 Age first had sexual intercourse

0.18

1.00

0.19

-

-

 Never eat sugar or foods/drinks containing sugar

0.54

0.22

0.58

-

-