Fig. 5
From: Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy
The NOTCH4 mutation was associated with high immune checkpoint expression in the TCGA cohort. A Volcano plots of 29 immune signatures estimated by the ssGSEA method based on RNA-sequencing data for NOTCH4-WT tumors and NOTCH4-MUT tumors. Immune signatures enriched in NOTCH4-MUT tumors are marked in red; immune signatures enriched in NOTCH4-WT tumors are marked in blue. B Volcano plots of 10 cell populations estimated by the MCP-counter method based on RNA-sequencing data for NOTCH4-WT tumors and NOTCH4-MUT tumors. Cell populations enriched in NOTCH4-MUT tumors are marked in red; cell populations enriched in NOTCH4-WT tumors are marked in blue. C Comparison of the expression of chemokines and interleukins between NOTCH4-WT and NOTCH4-MUT tumors. D Comparison of the expression of TCR richness between NOTCH4-WT and NOTCH4-MUT tumors. E Comparison of the expression of the TCR Shannon index between NOTCH4-WT and NOTCH4-MUT tumors. F Comparison of the cytolytic activity score between NOTCH4-WT and NOTCH4-MUT tumors. Statistical analysis of comparisons between two groups was conducted using the Wilcoxon test