Table 1 Overview on PheWAS results for nine metabolites significantly related to a 5-year tooth loss
From: Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting
| PheWAS variable | 2-Pyrrolidineacetic acid | X-23662 | Butyrylputrescine | N,N-dimethyl-5-aminovalerate | N-acetyl-cadaverine | N6,N6,N6-trimethyllysine | N-acetyltaurine | Phenylacetate | Dimethylarginine (SDMA + ADMA) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Smoking | Smoking (current) |
+ 0.0001 |
+ 0.031 |
+ 0.00013 |
+ 0.0011 |
+ 0.047 |
- 0.020 | |||
| Cardio-metabolic disorders | Known or diagnosed diabetes mellitus |
+ 0.030 | ||||||||
| Known diabetes mellitus |
+ 0.023 | |||||||||
| Diagnosed high blood pressure |
+ 0.026 | |||||||||
| Systolic blood pressure (mmHg) |
+ 0.026 |
+ 0.034 |
+ 0.023 | |||||||
| Triglycerides (total) (mmol/l) |
- 0.020 | |||||||||
| Inflammation | Fibrinogen acc. to Clauss (g/l) |
+ 0.026 |
+ 0.023 |
+ 0.019 | ||||||
| Leukocytes (Gpt/l) |
+ 0.03 |
+ 0.0003 |
+ 0.00044 |
+ 0.000004 |
+ 0.021 |
+ 0.002 | ||||
| Mean corpuscular haemoglobin (mmol/l) |
- 0.023 |
- 0.015 | ||||||||
| Red cell distribution width (%) |
+ 0.019 | |||||||||
| Obesity | Weight (kg) |
+ 0.003 |
+ 0.002 |
+ 0.015 | ||||||
| Waist circumference (cm) |
+ 0.0003 |
+ 0.0006 |
+ 0.023 |
+ 0.032 |
+ 0.019 | |||||
| Hip circumference (cm) |
+ 0.0067 |
+ 0.005 |
+ 0.032 |
+ 0.047 | ||||||
| Others | Bad breath |
+ 0.033 | ||||||||
| Sodium (mmol/l) |
+ 0.029 | |||||||||
| Serum amylase (μkatal/l) |
- 0.023 |