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Table 1 Overview on PheWAS results for nine metabolites significantly related to a 5-year tooth loss

From: Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting

 

PheWAS variable

2-Pyrrolidineacetic acid

X-23662

Butyrylputrescine

N,N-dimethyl-5-aminovalerate

N-acetyl-cadaverine

N6,N6,N6-trimethyllysine

N-acetyltaurine

Phenylacetate

Dimethylarginine (SDMA + ADMA)

Smoking

Smoking (current)

+

0.0001

+

0.031

+

0.00013

+

0.0011

+

0.047

 

-

0.020

  

Cardio-metabolic disorders

Known or diagnosed diabetes mellitus

 

+

0.030

       

Known diabetes mellitus

 

+

0.023

       

Diagnosed high blood pressure

 

+

0.026

       

Systolic blood pressure (mmHg)

 

+

0.026

  

+

0.034

+

0.023

   

Triglycerides (total) (mmol/l)

      

-

0.020

  

Inflammation

Fibrinogen acc. to Clauss (g/l)

  

+

0.026

  

+

0.023

  

+

0.019

Leukocytes (Gpt/l)

+

0.03

+

0.0003

+

0.00044

 

+

0.000004

+

0.021

  

+

0.002

Mean corpuscular haemoglobin (mmol/l)

 

-

0.023

  

-

0.015

    

Red cell distribution width (%)

        

+

0.019

Obesity

Weight (kg)

 

+

0.003

  

+

0.002

+

0.015

   

Waist circumference (cm)

 

+

0.0003

  

+

0.0006

+

0.023

 

+

0.032

+

0.019

Hip circumference (cm)

 

+

0.0067

  

+

0.005

+

0.032

  

+

0.047

Others

Bad breath

  

+

0.033

      

Sodium (mmol/l)

  

+

0.029

      

Serum amylase (μkatal/l)

     

-

0.023

   
  1. Only associations with q < 0.05 are listed. Plus sign: Beta (from linear regression models) >0; minus sign: Beta<0; Benjamini-Hochberg-adjusted p values are given (referred to as q value)