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Table 2 Cumulative incidence of cause-specific mortality at landmark ages

From: Temporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study

Age at diagnosis

AF diagnosis, < 1990, N = 683

AF diagnosis, 1990-2002, N = 711

AF diagnosis, ≥ 2003, N = 731

Ptrend value

< 70 years (cumulative incidence at age 75 years)

  

 CVD death

67.7 (40.8, 91.3)

17.9 (10.2, 30.4)

13.9 (6.9, 26.8)

< 0.001

 Non-CVD death

18.2 (6.9, 42.9)

41.8 (29.5, 56.7)

32.9 (20.6, 50.0)

0.07

 Unknown death

0.6 (0.2, 2.1)

3.2 (1.3, 8.0)

3.2 (0.9, 11.1)

0.74

Between 70 and < 80 years (cumulative incidence at age 85 years)

  

 CVD death

58.9 (48.0, 70.2)

27.4 (18.8, 39.1)

18.9 (9.0, 37.5)

< 0.001

 Non-CVD death

26.5 (18.7, 36.9)

44.5 (34.4, 55.9)

47.8 (27.0, 73.8)

0.30

 Unknown death

4.4 (2.2, 8.6)

4.7 (2.3, 9.2)

5.2 (2.5, 10.8)

0.86

≥ 80 years (cumulative incidence at age 95 years)

  

 CVD death

32.9 (14.4, 63.9)

56.9 (42.8, 71.9)

26.7 (14.9, 45.0)

0.76

 Non-CVD death

62.1 (36.2, 87.7)

34.3 (23.3, 48.4)

62.5 (44.5, 80.5)

0.002

 Unknown death

4.5 (1.7, 11.5)

6.4 (3.5, 11.4)

7.5 (3.5, 15.7)

0.83

  1. In each group according to age at AF diagnosis, we tested for linear trends over epochs of AF diagnosis in the cumulative incidence function for cause-specific death