|
AF cases, n = 1,920
|
CVD death (n = 599)
|
Non-CVD death (n = 722)
|
|---|
|
sHR
|
P value
|
sHR
|
P value
|
|---|
|
Age at diagnosis, years
|
6.33 (5.44, 7.37)
|
< 0.001
|
7.61 (6.54, 8.86)
|
< 0.001
|
|
Female
|
0.96 (0.80, 1.14)
|
0.60
|
1.06 (0.91, 1.25)
|
0.44
|
|
Systolic BP, mmHg
|
1.24 (0.81, 1.88)
|
0.32
|
0.91 (0.75, 1.10)
|
0.32
|
|
Diastolic BP, mmHg
|
1.05 (0.95, 1.16)
|
0.32
|
1.05 (0.95, 1.16)
|
0.32
|
|
Body mass index, kg/m2
|
0.98 (0.90, 1.08)
|
0.71
|
0.94 (0.86, 1.02)
|
0.14
|
|
Current smoker
|
0.95 (0.74, 1.22)
|
0.67
|
1.37 (1.11, 1.69)
|
0.004
|
|
Elevated alcohol consumption
|
0.86 (0.70, 1.06)
|
0.16
|
1.06 (0.88, 1.27)
|
0.55
|
|
Diabetes
|
1.18 (0.93, 1.48)
|
0.17
|
0.88 (0.70, 1.10)
|
0.26
|
|
Hypertension treatment
|
1.18 (0.99, 1.41)
|
0.06
|
0.86 (0.74, 1.01)
|
0.06
|
|
Prior heart failure
|
1.49 (1.14, 1.94)
|
0.003
|
0.70 (0.51, 0.96)
|
0.02
|
|
Prior myocardial infarction
|
1.44 (1.15, 1.80)
|
0.002
|
0.89 (0.71, 1.12)
|
0.32
|
|
Prior stroke or transient ischemic attack
|
1.27 (0.99, 1.64)
|
0.06
|
0.96 (0.75, 1.23)
|
0.75
|
|
Prior cancer
|
0.56 (0.46, 0.70)
|
< 0.001
|
1.94 (1.65, 2.28)
|
< 0.001
|
|
Secondary AF
|
0.92 (0.78, 1.10)
|
0.36
|
1.42 (1.22, 1.66)
|
< 0.001
|
|
Anticoagulation at diagnosis
|
1.00 (0.80, 1.24)
|
0.98
|
0.88 (0.72, 1.07)
|
0.20
|
|
Antiplatelet therapy at diagnosis
|
0.71 (0.57, 0.88)
|
0.002
|
0.99 (0.82, 1.18)
|
0.88
|
|
Epoch
| | | | |
|
1990–2002 vs. < 1990
|
0.69 (0.56, 0.85)
|
< 0.001
|
1.22 (1.01, 1.47)
|
0.04
|
|
≥ 2003 vs. < 1990
|
0.74 (0.57, 0.97)
|
0.03
|
1.18 (0.92, 1.52)
|
0.18
|
- Elevated alcohol consumption is defined as > 14 drinks/week for men and > 7 drinks/week for women
- For continuous covariates, the sHR corresponds to 1 standard deviation increase in the covariate (1 SD for age = 11.5 years, BMI 5.3 kg/m2, systolic blood pressure 22.9 mmHg, diastolic blood pressure 12.2 mmHg)
- This analysis included 1920 AF cases who attended an exam within 10 years prior to diagnosis. After a median follow-up of 4.8 years, 1493 AF cases had died (599 CVD death, 722 non-CVD death, 172 unknown cause) while 427 were still alive
- sHR subdistribution hazard ratio, BP blood pressure
