Table 1 New genome-wide significant loci identified in this study (a total of 17 novel risk loci)
Genomic locusa | Lead SNP | Chr | Pos | A1/A2(MAb) | MAF_Ac | MAF_Ud | P | ORe | Nearby gene(s)f |
|---|---|---|---|---|---|---|---|---|---|
1 | rs7192086 | 16 | 13061611 | T/A(T) | 0.32 | 0.28 | 4.92 × 10−08 | 1.22 | SHISA9 |
2 | rs57016637 | 22 | 30992925 | G/C(G) | 0.20 | 0.16 | 2.33 × 10−11 | 1.34 | SF3A1, CCDC157, RNF215, SEC14L2, MTFP1, SEC14L3, SEC14L6, GAL3ST1, PES1, TCN2, SLC35E4, DUSP18, OSBP2, MORC2 |
3 | rs115487049 | 2 | 76297343 | A/T(A) | 0.042 | 0.036 | 4.72 × 10−08 | 1.07 | SUCLA2P2 |
4 | rs10178509 | 2 | 236792838 | T/C(T) | 0.39 | 0.42 | 1.08 × 10−08 | 0.95 | AGAP1 |
5 | rs1426271 | 3 | 188187250 | A/G(G) | 0.35 | 0.33 | 3.23 × 10−08 | 0.95 | LPP |
6 | rs2911914 | 4 | 37820679 | T/G(T) | 0.25 | 0.27 | 2.12 × 10−08 | 0.95 | PGM2 |
7 | rs6848123 | 4 | 80203425 | A/C(C) | 0.14 | 0.16 | 1.17 × 10−08 | 1.05 | NAA11 |
8 | rs319227 | 5 | 146245762 | A/C(A) | 0.33 | 0.30 | 6.11 × 10−09 | 1.05 | PPP2R2B |
9 | rs12202107 | 6 | 130598623 | T/C(C) | 0.42 | 0.45 | 2.51 × 10−08 | 1.05 | SAMD3,TMEM200A |
10 | rs9386072 | 6 | 144859509 | A/T(A) | 0.43 | 0.47 | 1.01 × 10−08 | 0.93 | UTRN |
11 | rs2106747 | 7 | 23911499 | A/G(G) | 0.40 | 0.42 | 3.36 × 10−08 | 1.05 | TRA2A, FAM221A, STK31 |
12 | rs492430 | 7 | 100313099 | T/G(T) | 0.065 | 0.058 | 2.26 × 10−08 | 1.07 | ACTL6B, GNB2, GIGYF1, POP7, EPO |
13 | rs59761926 | 9 | 10238178 | T/C(T) | 0.37 | 0.39 | 3.02 × 10−09 | 0.95 | PTPRD |
14 | rs7301566 | 12 | 50581647 | T/C(T) | 0.099 | 0.091 | 2.91 × 10−08 | 1.06 | ASIC1, SMARCD1, GPD1, COX14, CERS5, LIMA1 |
15 | rs6563592 | 13 | 38814939 | T/G(G) | 0.31 | 0.30 | 2.13 × 10−08 | 0.95 | LINC00571 |
16 | rs2099108 | 14 | 81675420 | C/G(G) | 0.45 | 0.47 | 2.67 × 10−08 | 1.05 | GTF2A1,STON2 |
17 | rs6100546 | 20 | 58252407 | T/C(C) | 0.079 | 0.076 | 2.79 × 10−08 | 0.94 | PHACTR3 |