Table 3 Multivariable overall survival analysis in the TCGA cohort and GSE6891

121-Gene-Signatures

0.390

1.477 (1.004–2.172)

0.048

1.252

3.499 (2.043–5.992)

< 0.001

LSC17

− 0.989

0.372 (0.035–3.913)

0.410

− 0.009

0.991 (0.702–1.398)

0.959

Yang

0.955

2.599 (0.150–45.074)

0.512

− 0.777

0.460 (0.069–3.046)

0.421

Wang

0.322

1.381 (0.588–3.244)

0.459

0.146

1.157 (0.625–2.145)

0.642

ELN risk stratification

 Good

NA

NA

NA

− 0.317

0.729 (0.298–1.779)

0.487

 Intermediate

0.677

1.969 (0.822–4.714)

0.128

− 0.420

0.657 (0.310–1.395)

0.274

 Poor

0.742

2.099 (0.786–5.606)

0.139

− 0.616

0.540 (0.244–1.194)

0.128

Age (≥ 60 vs. < 60 years)

0.505

1.657 (0.981–2.799)

0.059

0.013

1.013 (0.999–1.027)

0.063

WBC (≥10 × 10⁹ vs. < 10 × 10⁹/L)

0.254

1.289 (0.764–2.175)

0.341

NA

NA

NA

BM blasts (≥ 50 vs. < 50%)

0.631

1.879 (0.853–4.140)

0.118

NA

NA

NA

PB blasts (≥ 40 vs. < 40%)

0.108

1.114 (0.633–1.962)

0.708

NA

NA

NA

FLT3_ITD (positive vs. negative)

0.003

1.003 (0.404–2.491)

0.994

− 0.220

0.803 (0.536–1.203)

0.287

NPM1 (mutated vs. wild)

− 0.242

0.785 (0.389–1.586)

0.500

0.478

1.613 (1.057–2.461)

0.027

DNMT3A (mutated vs. wild)

0.296

1.345 (0.788–2.295)

0.277

NA

NA

NA

RUNX1 (mutated vs. wild)

− 0.302

0.739 (0.307–1.783)

0.501

NA

NA

NA

CEBPA (mutated vs. wild)

NA

NA

NA

0.137

1.147 (0.448–2.936)

0.776

IDH1 (mutated vs. wild)

NA

NA

NA

− 0.389

0.678 (0.389–1.180)

0.169

IDH2 (mutated vs. wild)

NA

NA

NA

0.384

1.468 (0.817–2.637)

0.199

NRAS (mutated vs. wild)

NA

NA

NA

0.035

1.036 (0.596–1.801)

0.901

KRAS (mutated vs. wild)

NA

NA

NA

− 0.526

0.591 (0.179–1.955)

0.389