Outcome (n = 124,256) | Model 1a | Model 2b | Model 3c |
---|---|---|---|
HR (95% CI) | HR (95% CI) | HR (95% CI) | |
All-cause mortality | |||
No HF or LD use | Referent | Referent | Referent |
Isolated LD use | 2.10 (2.04–2.15)*** | 1.45 (1.41–1.51)*** | 1.42 (1.37–1.47)*** |
Diagnosed HF | 1.54 (1.47–1.63)*** | 1.36 (1.28–1.45)*** | 1.33 (1.26–1.42)*** |
Diagnosed HF + LD use | 2.79 (2.71–2.87)*** | 1.94 (1.87–2.00)*** | 1.78 (1.71–1.85)*** |
Unplanned HF hospitalisationΔ | |||
No HF or LD use | Referent | Referent | Referent |
Isolated LD use | 1.90 (1.73–2.09)*** | 1.63 (1.45–1.83)*** | 1.60 (1.42–1.80)*** |
Diagnosed HF | 3.39 (2.97–3.86)*** | 3.04 (2.62–3.53)*** | 3.01 (2.58–3.50)*** |
Diagnosed HF + LD use | 3.96 (3.63–4.32)*** | 3.18 (2.85–3.54)*** | 3.00 (2.65–3.40)*** |
Ischaemic strokeΔ | |||
No HF or LD use | Referent | Referent | Referent |
Isolated LD use | 0.99 (0.94–1.04) | 0.86 (0.81–0.91)*** | 0.88 (0.83–0.93)*** |
Diagnosed HF | 0.98 (0.90–1.07) | 1.00 (0.90–1.10) | 1.02 (0.92–1.13) |
Diagnosed HF + LD use | 0.81 (0.76–0.86)*** | 0.72 (0.68–0.78)*** | 0.78 (0.72–0.84)*** |