Table 3 Subgroup analysis: estimate of adjusted difference in mean HbA1c (mmol/mol) at 12 months between treatment arms by age, sex, deprivation score, and body mass index subgroup

Male

−0.13 (−2.38, 2.13)

0.42

−3.78 (−6.81, −0.74)

0.1

−3.90 (−6.91, −0.89)

0.29

−3.84 (−6.18, −1.49)

0.09

Female

−1.78 (−5.28, 1.72)

0.19 (−3.43, 3.82)

−1.58 (−4.59, 1.43)

−0.70 (−3.56, 2.17)

Age < 65 years

−2.55 (−5.55, 0.46)

0.15

−3.46 (−7.53, 0.62)

0.24

−6.01 (−9.56, −2.46)

0.007

−4.76 (−7.75, −1.78)

0.02

Age ≥ 65 years

0.46 (−2.25, 3.16)

−0.68 (−3.31, 1.96)

−0.22 (−2.70, 2.25)

−0.46 (−2.67, 1.75)

Deprivation quartile 1 (low)

−1.1 (−4.43, 2.24)

0.27

0.58 (−2.53, 3.68)

0.41

−0.52 (−3.96, 2.93)

0.48

0.07 (−2.78,2.92)

0.42

Deprivation quartile 2

2.2 (−0.82, 5.22)

−4.9 (−9.49, −0.31)

−2.7 (−7.4, 2.0)

−3.8 (−7.33, −0.27)

Deprivation quartile 3

−1.59 (−5.19, 2)

−1.94 (−5.96, 2.08)

−3.53 (−7.44, 0.37)

−2.72 (−5.84, 0.41)

Deprivation quartile 4 (high)

−3.29 (−9.34, 2.77)

−1.84 (−8.73, 5.06)

−5.13 (−10.23, −0.02)

−3.55 (−8.55, 1.45)

^aBody mass index quartile 1 (low)

−0.21 (−3.06, 2.65)

0.34

−0.25 (−2.79, 2.28)

0.23

−0.46 (−3.1, 2.18)

0.35

−0.34 (−2.46, 1.78)

0.21

Body mass index quartile 2

Body mass index quartile 3

Body mass index quartile 4 (high)