Table 2 Predictive value of HbA1c
Threshold (T) | Na | Percentage of participants classified as high-risk ≥ T (n) | n ≥ T who progress to diabetes | Sensitivity | Specificity | PPV | NPV | False positives | False negatives | AUC ROC |
|---|---|---|---|---|---|---|---|---|---|---|
HbA1c ≥ 39 mmol/molb (5.7%) | 4227 | 55.8% (n = 2358) | 137 | 95.1% (90.2, 98.0) | 45.6% (44.1, 47.1) | 5.8% (4.9, 6.8) | 99.6% (99.2, 99.8) | 54.4% (52.9,55.9) | 4.9% (2.0,9.8) | 70.4% (68.5,72.3) |
HbA1c ≥ 42 mmol/molc (6.0%) | 4227 | 22.0% (n = 929) | 115 | 79.9% (72.4, 86.1) | 80.1% (78.8, 81.3) | 12.4% (10.3, 14.7) | 99.1% (98.7, 99.4) | 19.9% (18.7,21.2) | 20.1% (13.9,27.6) | 80.0% (76.6, 83.3) |
HbA1c ≥ 44 mmol/mol (6.2%) | 4227 | 9.0% (n = 380) | 88 | 61.1% (52.6, 69.1) | 92.8% (92.0, 93.6) | 23.2% (19.0, 27.7) | 98.5% (98.1, 98.9) | 7.1% (6.4, 8.0) | 38.9% (30.9,47.3) | 77.0% (73.0, 81.0) |