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Fig. 4 | BMC Medicine

Fig. 4

From: Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals

Fig. 4

IgG subclass responses to SARS-CoV-2. A, B Dot plots of ELISA End Point titers calculated as the highest plasma dilution where the O.D. is 3× background. The bar represents the group median, and the points display individual data. Secondary antibodies specific for each IgG subclass (IgG1, IgG2, IgG3, IgG4) were used to determine subclass-specific responses. A Subclass responses to SARS-CoV-2 spike subunits (S1, S2) and nucleocapsid protein (NP) in SARS-CoV-2 infected individuals (n = 24) at baseline before the vaccine. B Subclass responses to SARS-CoV-2 receptor-binding domain (RBD) in SARS-CoV-2 infected individuals at baseline before vaccine (seropositive; n = 24) and three weeks after the first dose of BNT162b2 COVID-19 vaccine in seronegative individuals (vaccine; n = 24)

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