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Fig. 4 | BMC Medicine

Fig. 4

From: Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

Fig. 4

Complement fixation on VAR2CSA is associated with gravidity and P. falciparum peripheral infection status at enrolment. Complement C1q and C3 fixation was tested either on CS2 pRBCS by flow cytometry or on recombinant VAR2CSA-DBL5 (3D7) and VAR2CSA-DBL3 (7G8) domains by ELISA using samples from 302 PNG donors (primigravid n=115, multigravid n=187; non-infected=199, infected n=103). Complement A C1q and B C3 fixation on CS2 pRBCs by gravidity. Complement C1q fixation on C VAR2CSA-DBL5 (3D7) and D VAR2CSA-DBL3 (7G8) by gravidity. Complement E C1q and F C3 fixation on CS2 pRBCs by P. falciparum infection status at enrolment. Complement C1q fixation on G VAR2CSA-DBL5 (3D7) and H VAR2CSA-DBL3 (7G8) by P. falciparum infection status at enrolment. Data are presented as the average gMFI (flow cytometry) or optical density (OD; by ELISA) of each sample tested in duplicate and the red line represents the median gMFI or OD. P values were calculated using the Mann-Whitney U test

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BMC Medicine

ISSN: 1741-7015

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