Table 2 Ratio of means with 95% CIs of PANSS total scores compared between the four sources of data (individual participant data, clinical study report, journal publication and registry report)
Treatment | IPD vs. CSR | IPD vs. journal publication | IPD vs. registry report | CSR vs. journal publication | CSR vs. registry report | Journal publication vs. registry report |
|---|---|---|---|---|---|---|
Risperidone | 0.87 (− 0.37, 1.48) | 0.21 (− 0.05, 0.68) | NA | 0.38 (− 0.07, 0.81) | NA | NA |
Paliperidone | 0.29 (− 0.02, 0.60) | 0.11 (− 0.17, 0.87) | 0.49 (− 0.66, 1.24) | 0.49 (− 0.39, 1.37) | 0 (− 0.99, 0.99) | − 0.49 (− 1.75, 0.78) |
Paliperidone palmitate | 0.11 (− 0.13, 0.29) | 0.08 (− 0.17, 0.33) | 0.21 (− 0.53, 0.95) | 0 (− 0.23, 0.23) | 0.13 (− 0.22, 0.48) | 0.13 (− 0.25, 0.51) |