Table 3 Sectoral multivariable linear regression analyses for cardiometabolic biomarkers and cpRNFLT in all subjects (N = 8952)

Diabetes

− 0.81

0.056

− 0.79

0.114

− 1.18

0.115

− 2.05

0.013

− 0.57

0.332

− 0.50

0.552

− 0.05

0.940

Smoking status

0.58

0.053

− 0.75

0.047

0.41

0.450

0.63

0.295

1.05

0.033

1.31

0.047

1.70

0.024

Hypertension

− 0.41

0.235

− 0.26

0.671

− 0.02

0.965

− 0.85

0.235

− 0.83

0.140

− 0.17

0.911

− 0.14

0.911

BMI (kg/m²)

0.06

0.035

− 0.03

0.294

0.08

0.152

0.07

0.201

0.04

0.254

0.14

0.018

0.15

0.014

WHR

2.08

0.330

− 3.62

0.212

1.13

0.780

0.96

0.780

3.63

0.258

8.40

0.144

6.12

0.212

SBP (mmHg)

− 0.01

0.232

− 0.02

0.220

− 0.02

0.220

− 0.02

0.232

− 0.01

0.282

0.00

0.820

0.02

0.220

DBP (mmHg)

0.00

0.927

− 0.02

0.605

0.01

0.927

0.00

0.927

0.00

0.927

− 0.03

0.605

0.05

0.312

Cystatin C (mg/l)

− 2.18

< 0.001

− 2.04

0.006

− 3.06

0.008

− 4.47

< 0.001

− 0.75

0.358

− 1.24

0.337

− 3.23

0.008

eGFR_Cys (ml/min per 1.73 m²)

0.03

< 0.001

0.03

0.001

0.04

0.006

0.06

< 0.001

0.01

0.238

0.01

0.590

0.04

0.007

Albumin-creatinine ratio (mg/g)

0.00

0.916

0.00

0.916

0.00

0.916

0.00

0.916

0.00

0.686

0.00

0.953

0.00

0.916

eGFR category (G1–G5)

− 0.93

< 0.001

− 1.04

< 0.001

− 1.36

0.001

− 2.07

< 0.001

− 0.18

0.550

− 0.36

0.467

− 1.27

0.004

Presence of CKD (yes/no)

− 2.06

< 0.001

− 1.16

0.026

− 2.70

0.001

− 5.24

< 0.001

− 0.88

0.133

− 1.65

0.059

− 2.80

0.002

Fasting glucose (mmol/l)

0.04

0.731

− 0.14

0.453

− 0.11

0.661

− 0.23

0.453

0.19

0.453

0.28

0.453

0.21

0.453

Fasting insulin (pmol/l)

0.00

0.409

0.00

0.458

0.00

0.260

0.00

0.437

0.00

0.868

0.01

0.223

0.00

0.868

HbA1c (%)

0.19

0.612

0.29

0.612

− 0.05

0.905

− 0.08

0.905

0.43

0.612

− 0.33

0.612

0.43

0.612

Total cholesterol (mmol/l)

0.42

< 0.001

0.03

0.803

0.63

0.004

0.36

0.102

0.28

0.096

0.74

0.002

1.00

< 0.001

HDL cholesterol (mmol/l)

− 0.58

0.044

− 0.14

0.760

− 1.29

0.034

− 1.30

0.034

− 0.01

0.979

− 1.32

0.034

− 0.41

0.617

Non-HDL cholesterol (mmol/l)

0.49

< 0.001

0.06

0.623

0.82

< 0.001

0.56

0.009

0.27

0.086

0.91

< 0.001

1.01

< 0.001

LDL cholesterol (mmol/l)

0.51

< 0.001

0.24

0.107

0.74

0.002

0.71

0.004

0.26

0.121

0.56

0.032

1.08

< 0.001

TG (mmol/l)

0.22

0.082

− 0.16

0.289

0.44

0.075

0.10

0.635

0.16

0.370

0.70

0.013

0.51

0.075

ApoA1 (g/l)

− 0.66

0.190

− 1.04

0.126

− 1.46

0.149

− 1.81

0.126

− 0.17

0.907

− 0.03

0.976

0.43

0.856

ApoB (g/l)

1.92

< 0.001

0.13

0.798

2.92

0.001

2.14

0.016

1.32

0.037

3.65

< 0.001

3.84

< 0.001

Lp(a) (g/l)

0.21

0.887

0.22

0.887

− 0.21

0.887

0.39

0.887

0.07

0.887

0.58

0.887

0.20

0.887

hsCRP (mg/l)

0.03

0.477

0.00

0.919

0.04

0.477

− 0.01

0.919

0.02

0.612

0.06

0.477

0.06

0.477

IL-6 (ng/l)

0.00

0.998

− 0.01

0.920

0.04

0.920

− 0.03

0.920

− 0.03

0.920

0.07

0.920

0.00

0.998

ALAT (μkat/l)

0.18

0.982

− 0.44

0.982

− 0.03

0.982

0.51

0.982

0.23

0.982

− 0.02

0.982

1.37

0.961

ASAT (μkat/l)

− 0.47

0.709

− 0.86

0.709

− 0.14

0.920

− 1.03

0.709

− 0.74

0.709

0.60

0.853

0.12

0.920

AP (μkat/l)

− 0.13

0.894

− 0.30

0.894

− 0.38

0.894

0.09

0.894

− 0.22

0.894

0.09

0.894

0.16

0.894

GGT (μkat/l)

0.01

0.918

− 0.30

0.287

− 0.16

0.773

0.06

0.918

− 0.13

0.773

0.33

0.597

0.80

0.045