Fig. 2

The long-term cumulative incidence of fractures stratified according to previous hospitalisations due to unexplained syncope and orthostatic hypotension. Kaplan-Meier curves depicting the long-term cumulative incidence of fractures stratified according to previous hospitalisations resulting from unexplained syncope (green, n = 493) and orthostatic hypotension (OH; red, n = 406) among 30,399 middle-aged individuals (mean age, 57.5 ± 7.6; women, 60.2%). A significantly higher incidence of fractures in individuals previously hospitalised due to unexplained syncope and orthostatic hypotension (log-rank test: p < 0.001) was observed with both survival curves diverging from the control group around 12 years from inclusion, i.e. the median time between baseline and syncope or orthostatic hypotension, and a second diversion between unexplained syncope and orthostatic hypotension was observed at 15 years