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Fig. 2 | BMC Medicine

Fig. 2

From: Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms

Fig. 2

Statistically significant differential expression of proteins in renal neoplasms. A Hierarchical clustering analysis of 850 differentially expressed proteins (ANOVA, FDR < 1%) according to the tissue source. B Statistical proteomic workflow to select panels of proteins to discriminate between the four renal neoplasm subtypes and normal adjacent tissue (NAT). C TPA-based concentrations of the proteins with the highest differential expression between tissue biopsies (fold change) for each subtype. Clear cell renal cell carcinoma (ccRCC, FC ≥ 5); papillary renal cell carcinoma (pRCC, FC ≥ 9); chromophobe renal cell carcinoma (chRCC, FC ≥ 4); renal oncocytoma (RO, FC ≥ 3), additional file 7: Fig. S2. Absolute protein concentration expressed in pmol/mg of total protein was calculated with the TPA method [24]

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BMC Medicine

ISSN: 1741-7015

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