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Table 2 Adjusted hazard ratios (HRs) for incident liver diseases associated with alcohol drinking status, in men

From: Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults

  

Abstainers

Ex-regular drinkers

Occasional drinkers

Current regular drinkers

 

All N

N

HR (95% CI)

N

HR (95% CI)

N

HR (95% CI)

N

HR (95% CI)

P valuea

HR (95% CI) per 280 g/week

P trendb

Liver cancer

1592

365

1.00 (0.90–1.12)

203

1.24 (1.08–1.43)

477

0.86 (0.78–0.94)

547

1.07 (0.98–1.17)

0.364

1.44 (1.23–1.69)

< 0.001

Liver cirrhosis

1098

291

1.00 (0.88–1.14)

112

0.97 (0.81–1.18)

307

0.68 (0.60–0.76)

388

0.96 (0.86–1.07)

0.645

1.83 (1.60–2.09)

< 0.001

Alcoholic liver disease

239

10

1.00 (0.53–1.87)

15

3.72 (2.24–6.20)

14

1.11 (0.65–1.88)

200

14.03 (12.00–16.41)

< 0.001

2.01 (1.77–2.28)

< 0.001

Non-alcoholic fatty liver disease

440

64

1.00 (0.77–1.30)

67

1.73 (1.35–2.22)

111

0.91 (0.75–1.10)

198

1.07 (0.93–1.24)

0.645

1.71 (1.35–2.16)

< 0.001

Chronic viral hepatitis

778

162

1.00 (0.85–1.18)

82

1.30 (1.04–1.62)

308

1.00 (0.89–1.13)

226

0.86 (0.75–0.99)

0.196

1.23 (0.94–1.60)

0.135

Total liver disease

4641

1021

1.00 (0.94–1.07)

513

1.16 (1.06–1.27)

1332

0.83 (0.79–0.88)

1775

1.07 (1.01–1.12)

0.136

1.52 (1.40–1.64)

< 0.001

  1. HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen
  2. Participants with unclear or missing HBsAg test result, or with self-reported prior cancer, liver cirrhosis, or chronic hepatitis were excluded
  3. Cox models are stratified by age-at-risk, study area, and HBsAg, and adjusted for education, household income, smoking, body mass index, and physical activity
  4. aP for association comparing current regular drinkers vs. abstainers
  5. bP for alcohol consumption (g/week) modelled as a continuous variable among current regular drinkers