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Fig. 1 | BMC Medicine

Fig. 1

From: The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

Fig. 1

Experimental overview of human fetal adrenal ex vivo culture approach and the selected inhibitors. a Illustration of the hanging drop culture approach and measurements of steroid hormones by LC-MS/MS in the media. b Overview of media collection days and treatment setups under basal and ACTH-stimulated conditions. Media were pooled from all technical replicates collected throughout the experimental period of 14 days. c Overview of classic adrenal steroidogenesis. Arrows indicate enzyme reactions; stippled arrow indicates enzyme reaction with low substrate affinity. Colored crosses indicate enzymes expected to be inhibited by the selected inhibitors. Blue: Abiraterone acetate, magenta: Osilodrostat, orange: Efavirenz

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