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Table 2 Association of the frailty index (FI) with the risk of dementia in the full sample (left panel) and in the genotyped sample I adjusting for the APOE ɛ4 carrier status (right panel). Hazard ratios (HRs) from the Cox regression and 95% confidence intervals (CIs) are presented for a 10% increase in FI

From: Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?

  Multivariate Cox models Multivariate Cox models adjusting for the APOE ɛ4 carrier status
Full sample (N = 41,550) Genotyped sample I (N = 11,502)
Model 1 Model 2 Model 1 Model 2
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
FI 1.19 (1.14, 1.24)* 1.17 (1.13, 1.23)* 1.13 (1.04, 1.23)* 1.13 (1.03, 1.23)*
Age at FI measurement 1.15 (1.14, 1.16)* 1.15 (1.14, 1.16)* 1.15 (1.14, 1.16)* 1.16 (1.15, 1.17)*
Male sex 0.85 (0.78, 0.91)* 0.87 (0.80, 0.94)* 0.83 (0.72, 0.97) 0.82 (0.71, 0.96)*
Education years   0.97 (0.96, 0.98)* 0.98 (0.96, 1.00) 0.98 (0.96, 1.00)
Tobacco user   1.19 (1.10, 1.29)* 1.17 (1.01,1.35)* 1.16 (1.00, 1.34)*
APOE ɛ4 status (ref. non-carrier)     
Heterozygous (ɛ2/ɛ4 or ɛ3/ɛ4)     2.04 (1.75, 2.37)*
Homozygous (ɛ4/ɛ4)     7.02 (5.21, 9.46)*
  1. Note. Model 1 in each sample adjusts for age and sex and model 2 adjusts additionally for education and tobacco use. Model 1 for the genotyped sample represents the FI-dementia association in this sample without adjusting for the APOE ɛ4 status and model 2 adjusts for the APOE ɛ4 status. *P < 0.05