Table 2 Association of the frailty index (FI) with the risk of dementia in the full sample (left panel) and in the genotyped sample I adjusting for the APOE ɛ4 carrier status (right panel). Hazard ratios (HRs) from the Cox regression and 95% confidence intervals (CIs) are presented for a 10% increase in FI

FI

1.19 (1.14, 1.24)*

1.17 (1.13, 1.23)*

1.13 (1.04, 1.23)*

1.13 (1.03, 1.23)*

Age at FI measurement

1.15 (1.14, 1.16)*

1.15 (1.14, 1.16)*

1.15 (1.14, 1.16)*

1.16 (1.15, 1.17)*

Male sex

0.85 (0.78, 0.91)*

0.87 (0.80, 0.94)*

0.83 (0.72, 0.97)

0.82 (0.71, 0.96)*

Education years

0.97 (0.96, 0.98)*

0.98 (0.96, 1.00)

0.98 (0.96, 1.00)

Tobacco user

1.19 (1.10, 1.29)*

1.17 (1.01,1.35)*

1.16 (1.00, 1.34)*

APOE ɛ4 status (ref. non-carrier)

Heterozygous (ɛ2/ɛ4 or ɛ3/ɛ4)

2.04 (1.75, 2.37)*

Homozygous (ɛ4/ɛ4)

7.02 (5.21, 9.46)*