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Table 1 The characteristics of participants

From: Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study

Parameters

Marker selection

Training set

Test set

Independent validation set

Cancer (n = 24)

Cancer (n = 43)

Control (n = 67)

P value

Cancer (n = 42)

Control (n = 68)

P value

Cancer (n = 83)

Control (n = 98)

Age, n (%)

   

0.29

  

0.22

  

 ≥ 55

23 (96%)

33 (77%)

44 (66%)

 

31 (74%)

41 (60%)

 

77 (92.8%)

57 (58.2%)

 40–55

1 (4%)

10 (23%)

23 (34%)

 

11 (26%)

27 (40%)

 

6 (7.2%)

41 (41.8%)

Sex, n (%)

   

0.002

  

1.00

  

 Female

6 (25%)

7 (16%)

31 (46%)

 

14 (33%)

23 (34%)

 

32 (38.6%)

52 (53.1%)

 Male

18 (75%)

36 (84%)

36 (54%)

 

28 (67%)

45 (66%)

 

51 (61.4%)

46 (46.9%)

Smoking history, n (%)

   

0.02

  

0.44

  

 Smokers

6 (25%)

12 (28%)

7 (10%)

 

9 (21%)

10 (15%)

 

24 (28.9%)

39 (39.8%)

 Non-smokers

18 (75%)

31 (72%)

60 (90%)

 

33 (79%)

58 (85%)

 

52 (62.7%)

59 (60.2%)

 Unknown

       

7 (8.4%)

 

Alcohol history, n (%)

   

1.00

  

0.10

  

 Drinkers

0

4 (9%)

7 (10%)

 

3 (7%)

13 (19%)

 

14 (16.9%)

48 (49.0%)

 Non-drinkers

24 (100%)

39 (91%)

60 (90%)

 

39 (93%)

55 (81%)

 

59 (71.1%)

50 (51.0%)

 Unknown

       

10 (12.0%)

 

Pathological type

         

 ESCC, n (%)

22 (92%)

39 (91%)

  

38 (90%)

  

72 (86.7%)

 

 EAC, n (%)

2 (8%)

4 (9%)

  

4 (10%)

  

8 (9.6%)

 

 Others, n (%)

       

3 (3.6%)

 

Stage, n (%)

         

 Stage 0

4 (17%)

3 (7%)

  

2 (5%)

  

10 (12.0%)

 

 Stage I

13 (54%)

9 (21%)

  

8 (19%)

  

14 (16.9%)

 

 Stage II

4 (17%)

11 (26%)

  

13 (31%)

  

27 (32.5%)

 

 Stage III

2 (8%)

12 (28%)

  

7 (17%)

  

14 (16.9%)

 

 Stage IV

1 (4%)

8 (19%)

  

6 (14%)

  

18 (21.7%)

 

 Unknown

         

Healthy control, n (%)

  

62 (93%)

  

63 (93%)

  

98 (100%)

Benign disease, n (%)

  

5 (7%)

  

5 (7%)

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