Fig. 4

Projected epidemiological impact of a comprehensive one-time intervention to find and treat TB and LTBI. The projected TB incidence rate (A) and TB-related mortality rate (B), per 100,000 per year between 2000 and 2040, in model simulations without the intervention (gray) and in simulations with the intervention implemented in 2020 (red). Percentage reductions in annual TB incidence (C) and TB-related mortality (D) rates (red). Also shown are simulated interventions which (hypothetically) focused solely on treating adults for LTBI with no effect on active TB, represented by adult preventive therapy (PT) in Fig. 3 (blue), or focused solely on active case finding (ACF) and child contact tracing (CCT), represented by ACF and CCT arms in Fig. 3 (yellow). The cumulative impact is shown as cumulative TB cases averted (E) and cumulative TB-related deaths averted (F), for the full rapid one-time intervention (red) and for its PT (blue) and ACF/CCT (yellow) components separately