From: Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet
CD patients | Non-CD controls | ||||||
---|---|---|---|---|---|---|---|
Total | Marsh 3 | Marsh 1 | Total | Healthy | NR-GFD | R-GFD | |
N = 22 | N = 14 | N = 8 | N = 48 | N = 13 | N = 21 | N = 14 | |
Age† (years) | |||||||
Mean ± SE | 50.4 ± 3.5 | 49.3 ± 4.2 | 52.0 ± 6.4 | 38.3 ± 1.9 | 40.0 ± 3 .7 | 35.5 ± 2.5 | 40.5 ± 4.0 |
Range | 24–83 | 24–69 | 31–83 | 16–63 | 23–63 | 16–49 | 19–62 |
Age at diagnosis (years) | |||||||
Mean ± SE | 41.8 ± 3.8 | 40.1 ± 4.5 | 44.7± 7.1 | -- | -- | -- | -- |
Range | 15–80 | 15–65 | 22–80 | ||||
Females (N, %) | 16 (72.7) | 10 (71) | 6 (75) | 37 (77.1) | 10 (77) | 14 (67) | 13 (93) |
ATG2 positive (N, %) | 22 (100)‡ | 14 (100)‡ | 8 (100) | 0 | 0 | 0 | 0 |
HLA (N, %) | |||||||
DQ2.5 | 20 (91.0) | 13 (93) | 7 (87.5) | 21 (44.7) | 8 (62) | 10 (50) | 3 (21) |
DQ8 | 0 | 0 | 0 | 5 (10.6) | 0 | 3 (15) | 2 (14) |
DQ2.2 | 1 (4.5) | 1 (7) | 0 | 7 (14.9) | 1 (8) | 2 (10) | 4 (29) |
DQ7.5 | 0 | 0 | 0 | 4 (8.5) | 1 (8) | 1 (5) | 2 (14) |
Non-DQ2/DQ8 | 1 (4.5) | 0 | 1 (12.5) | 10 (21.3) | 3 (23) | 4 (20) | 3 (21) |
Histology (N, %)§ | |||||||
ND | 0 | 0 | 0 | 16 (33.3) | 13 (100) | 0 | 3 (21) |
Marsh 0 | 0 | 0 | 0 | 21 (43.8) | 0 | 14 (67) | 7 (50) |
Marsh 1 | 8 (36.4) | 0 | 8 (100) | 11 (22.9) | 0 | 6 (29) | 4 (29) |
Marsh 3a | 5 (22.7) | 5 (38) | 0 | 0 | 0 | 0 | 0 |
Marsh 3b | 4 (18.2) | 4 (31) | 0 | 0 | 0 | 0 | 0 |
Marsh 3c | 4 (18.2) | 4 (31) | 0 | 0 | 0 | 0 | 0 |
Time on GFD | |||||||
Mean ± SE (years) | 7.4 ± 1.3 | 8.0 ± 1.7 | 6.2 ± 2.0 | 1.8 ± 0.4 | 0.09 ± 0.005 | 2.6 ± 0.6 | 2.7 ± 0.8 |
Range | 1–25 years | 1–25 years | 1–16 years | 1 month–11 years | 30–45 days | 1 month–6 years | 4 months–11 years |