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Table 1 Characteristics of the participants in the study

From: Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet

 

CD patients

Non-CD controls

Total

Marsh 3

Marsh 1

Total

Healthy

NR-GFD

R-GFD

N = 22

N = 14

N = 8

N = 48

N = 13

N = 21

N = 14

Age(years)

       

 Mean ± SE

50.4 ± 3.5

49.3 ± 4.2

52.0 ± 6.4

38.3 ± 1.9

40.0 ± 3 .7

35.5 ± 2.5

40.5 ± 4.0

 Range

24–83

24–69

31–83

16–63

23–63

16–49

19–62

Age at diagnosis (years)

       

 Mean ± SE

41.8 ± 3.8

40.1 ± 4.5

44.7± 7.1

--

--

--

--

 Range

15–80

15–65

22–80

    

Females (N, %)

16 (72.7)

10 (71)

6 (75)

37 (77.1)

10 (77)

14 (67)

13 (93)

ATG2 positive (N, %)

22 (100)‡

14 (100)‡

8 (100)

0

0

0

0

HLA (N, %)

       

 DQ2.5

20 (91.0)

13 (93)

7 (87.5)

21 (44.7)

8 (62)

10 (50)

3 (21)

 DQ8

0

0

0

5 (10.6)

0

3 (15)

2 (14)

 DQ2.2

1 (4.5)

1 (7)

0

7 (14.9)

1 (8)

2 (10)

4 (29)

 DQ7.5

0

0

0

4 (8.5)

1 (8)

1 (5)

2 (14)

 Non-DQ2/DQ8

1 (4.5)

0

1 (12.5)

10 (21.3)

3 (23)

4 (20)

3 (21)

Histology (N, %)§

       

 ND

0

0

0

16 (33.3)

13 (100)

0

3 (21)

 Marsh 0

0

0

0

21 (43.8)

0

14 (67)

7 (50)

 Marsh 1

8 (36.4)

0

8 (100)

11 (22.9)

0

6 (29)

4 (29)

 Marsh 3a

5 (22.7)

5 (38)

0

0

0

0

0

 Marsh 3b

4 (18.2)

4 (31)

0

0

0

0

0

 Marsh 3c

4 (18.2)

4 (31)

0

0

0

0

0

Time on GFD

       

 Mean ± SE (years)

7.4 ± 1.3

8.0 ± 1.7

6.2 ± 2.0

1.8 ± 0.4

0.09 ± 0.005

2.6 ± 0.6

2.7 ± 0.8

 Range

1–25 years

1–25 years

1–16 years

1 month–11 years

30–45 days

1 month–6 years

4 months–11 years

  1. Abbreviations: CD, coeliac disease; GFD, gluten-free diet; NR-GFD, disease controls with no clinical response to a GFD; R-GFD, disease controls with a clinical response to a GFD; ND, not done; ATG2, antibodies against transglutaminase type 2; DQ2.5 = DQB1*02 and DQA1*05; DQ8 = DQB1*03:02-DQA1*03; DQ2.2 = DQB1*02:02-DQA1*02:01; DQ7.5 = DQB1*03:01-DQA1*05
  2. †Age at the moment of the gluten challenge; ‡one patient only had anti-endomysial antibodies tested (with a positive result); §one patient had Marsh 3 with no information about the subtype